Docetaxel (trade name Taxotere) is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel has an approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed.
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- (2R,3S)-N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5, 20-epoxy-1, 2, 4, 7, 10, 13-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate, trihydrate
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- (2R,3S)-N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5, 20-epoxy-1, 2, 4, 7, 10, 13-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate, trihydrate
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- Docetaxel (trade name Taxotere) is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel has an approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed. Administered as a one-hour infusion every three weeks generally over a ten cycle course, docetaxel is considered as or more effective than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule agent. Docetaxel is marketed worldwide under the name Taxotere by Sanofi-Aventis. Annual sales approx $2bn. Patent expires in 2010.
- Docetaxel (Handelsname Taxotere, Fa. sanofi-aventis) ist ein Zytostatikum aus der Gruppe der Taxane. Es wird semisynthetisch aus der Europäischen Eibe gewonnen.
- Docetaxel je polosyntetická látka vzniklá úpravou molekuly alkaloidu paclitexelu, látky ze skupiny taxanů. V medicíně je využíván jako cytostatikum
- Doketakseli (lääkeyhtiö Sanofi-Aventis käyttämä lääkkeen kaupallinen nimi Taxotere®) on paklitakselin puolisynteettinen analogi, jonka esiaste 10-deasetyylibakkatiini III (C29H36O10, CAS-numero 32981-86-5) on eristetty euroopanmarjakuusen (Taxus baccata) neulasista. Doketakseli on solunsalpaaja, jota käytetään mm. rintasyövän hoidossa. Doketakselin kemiallinen kaava on C43H53NO14 ja CAS-numero 114977-28-5.
- Le docétaxel est une substance active anticancéreuse. C’est un alcaloïde synthétisé en France (1989), appartenant à la famille des taxanes, par hémisynthèse à partir des aiguilles de l’if européen (Taxus baccata). Le docétaxel est un analogue du paclitaxel, de structure et d’activité voisines, mais il en diffère surtout par sa toxicité et son efficacité antitumorale. Comme lui, il favorise le maintien des microtubules en inhibant leur dépolymérisation par liaison stable à la tubuline et entraîne un blocage de la mitose. Il est utilisé à la dose de 100 mg/m² toutes les 3 semaines par voie veineuse, en perfusion d’une heure. Il est toxique pour la moelle osseuse et entraîne des réactions d’hypersensibilité, une rétention d’eau avec œdèmes et épanchements et des troubles neurologiques. Il est efficace dans de nombreuses tumeurs mais principalement dans les cancers du sein métastatiques, résistant aux anthracyclines ou en rechute, dans le cancer du poumon et de la prostate.
- ドセタキセル（docetaxel）は、タキサン系の抗がん剤。 商品名タキソテール。 先行して開発されたタキソール(一般名パクリタキセル）と名称が非常に似ていて、作用機序も同じだが、抗腫瘍効果や溶解性の点で改良がなされており、しびれなどの副作用も少なく、臨床効果も高いという報告がある。
- O docetaxel é um agente antineoplásico que é usado no tratamento de vários tipos de cancros, nomeadamente no carcinoma da mama, do pulmão de células não-pequenas, da próstata, da cabeça e pescoço e adenocarcinoma gástrico. O docetaxel tem também actividade clínica contra o carcinoma dos ovários e da bexiga. O tratamento com este fármaco oferece vários benefícios, tais como: Aumento da esperança de vida dos doentes Diminuição do tumor e da sua progressão Diminuição do risco de recidivas. O docetaxel é uma substância semi-sintética derivada das agulhas das árvores do teixo (Taxus baccata). Por essa razão, pertence à família dos taxanos e ao grupo de medicamentos antineoplásicos chamado taxóides, no qual também, se inclui o paclitaxel (também denominado de taxol). A sua fórmula química é (2R,3S)-N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5, 20-epoxy-1, 2, 4, 7, 10, 13-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate, trihydrate.
- Доцетаксел — цитостатический препарат растительного происхождения из группы таксанов.
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- 2R,3S)-N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5, 20-epoxy-1, 2, 4, 7, 10, 13-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate, trihydrate
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- Docetaxel (trade name Taxotere) is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel has an approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed.
- Docetaxel (Handelsname Taxotere, Fa. sanofi-aventis) ist ein Zytostatikum aus der Gruppe der Taxane. Es wird semisynthetisch aus der Europäischen Eibe gewonnen.
- Docetaxel je polosyntetická látka vzniklá úpravou molekuly alkaloidu paclitexelu, látky ze skupiny taxanů. V medicíně je využíván jako cytostatikum
- Doketakseli (lääkeyhtiö Sanofi-Aventis käyttämä lääkkeen kaupallinen nimi Taxotere®) on paklitakselin puolisynteettinen analogi, jonka esiaste 10-deasetyylibakkatiini III (C29H36O10, CAS-numero 32981-86-5) on eristetty euroopanmarjakuusen (Taxus baccata) neulasista. Doketakseli on solunsalpaaja, jota käytetään mm. rintasyövän hoidossa. Doketakselin kemiallinen kaava on C43H53NO14 ja CAS-numero 114977-28-5.
- Le docétaxel est une substance active anticancéreuse. C’est un alcaloïde synthétisé en France (1989), appartenant à la famille des taxanes, par hémisynthèse à partir des aiguilles de l’if européen (Taxus baccata). Le docétaxel est un analogue du paclitaxel, de structure et d’activité voisines, mais il en diffère surtout par sa toxicité et son efficacité antitumorale.
- ドセタキセル（docetaxel）は、タキサン系の抗がん剤。 商品名タキソテール。 先行して開発されたタキソール(一般名パクリタキセル）と名称が非常に似ていて、作用機序も同じだが、抗腫瘍効果や溶解性の点で改良がなされており、しびれなどの副作用も少なく、臨床効果も高いという報告がある。
- O docetaxel é um agente antineoplásico que é usado no tratamento de vários tipos de cancros, nomeadamente no carcinoma da mama, do pulmão de células não-pequenas, da próstata, da cabeça e pescoço e adenocarcinoma gástrico. O docetaxel tem também actividade clínica contra o carcinoma dos ovários e da bexiga.
- Доцетаксел — цитостатический препарат растительного происхождения из группы таксанов.
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- Docetaxel
- Docetaxel
- Docetaxel
- Doketakseli
- Docétaxel
- ドセタキセル
- Docetaxel
- Доцетаксел
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