Butorphanol (AAN, BAN, INN and USAN) is a morphinan-type synthetic opioid analgesic developed by Bristol-Myers. Brand name Stadol was recently discontinued by the manufacturer. It is now only available in its generic formulations, manufactured by Novex, Mylan, Apotex and Ben Venue Laboratories. Butorphanol is most closely structurally related to levorphanol. Butorphanol is available as the tartrate salt in injectable, tablet, and intranasal spray formulations. The tablet form is only used in dogs and cats due to low bioavailability in humans.

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dbo:abstract
  • بوتورفانول Butorphanol أو Stadol هو مسكن أفيوني اصطناعي, مشابه كيميائيا لليفورفانول levorphanol. (AAN، BAN، INN و USAN) هو مورفين - نوع اصطناعي من الافيونيات المسكنات تم تطويره من قبل بريستول مايرز فعال في تسكين الألم عند النساء أكثر من الرجال. يُؤَثِّر الدَّواءُ في مَراكِز معيَّنة في الجهاز العصبي المركزي لتخفيف الألم، حيث يتَّحِد مع مستقبلات الأفيون في الدِّماغ لمنع انتقال إشارات الألم. هو من المُنَبِّهات الأفيونيَّة الجزئيَّة Opiate Partial Agonists. يفيد في تَسكين الألم، مثل المورفين. (ar)
  • Le butorphanol est un dérivé agoniste-antagoniste opioïde ayant une activité μ-antagoniste, κ-agoniste et σ-agoniste, contrairement à la plupart des opiacés, lui permettant d'être utilisé comme analgésique. (fr)
  • Butorphanol ist ein stark wirksames Schmerzmittel (Analgetikum) aus der Gruppe der Opioide. Es wirkt als ein Agonist am κ- und δ-Opioid-Rezeptor und ein Antagonist am μ−Opioid-Rezeptor. Butorphanol wird als Tierarzneimittel verwendet. (de)
  • Butorphanol (AAN, BAN, INN and USAN) is a morphinan-type synthetic opioid analgesic developed by Bristol-Myers. Brand name Stadol was recently discontinued by the manufacturer. It is now only available in its generic formulations, manufactured by Novex, Mylan, Apotex and Ben Venue Laboratories. Butorphanol is most closely structurally related to levorphanol. Butorphanol is available as the tartrate salt in injectable, tablet, and intranasal spray formulations. The tablet form is only used in dogs and cats due to low bioavailability in humans. Butorphanol is listed under the Single Convention on Narcotic Drugs 1961 and in the United States is a Schedule IV Narcotic controlled substance with a DEA ACSCN of 9720; being in Schedule IV it is not subject to annual aggregate manufacturing quotas. The free base conversion ratio of the hydrochloride is 0.69. Butorphanol was originally in Schedule II and at one point it was decontrolled. Butorphanol derived from thebaine was scheduled separately as Schedule II, then decontrolled on 14. July 1992 and put in Schedule IV on 31. October 1997. (en)
  • Il Butorfanolo è un analgesico oppiaceo di origine sintetica ideato da Bristol-Myers. Il suo nome commerciale inizialmente fu “Stadol”, ma recentemente è disponibile nelle sue formulazioni generiche prodotte da diverse case farmaceutiche. Il Butorfanolo è strutturalmente molto simile al Levorfanolo. Chimicamente il Butorfanolo è disponibile sotto forma di sale di tartrato e può essere presente in spray intranasale, in compresse oppure può essere iniettabile. Le compresse vengono utilizzate in medicina veterinaria, per cani e gatti. Questa molecola fa parte della categoria degli stupefacenti dal 1961 e negli Stati Uniti è una sostanza facente parte dell'allegato 4 dal 31 ottobre 1997. (it)
  • Butorfanol is een synthetisch opioïde met μ-antagoniste, κ-agoniste en σ-agoniste activiteiten. (nl)
  • Буторфанол — лекарственное средство, опиоидный анальгетик. (ru)
  • Butorfanol é um fármaco agonista parcial utilizado pela medicina humana e pela medicina veterinária como analgésico opioide, é utilizado também para promover a analgesia em gatos. (pt)
  • Butorfanol (łac. Butorphanolum) – organiczny związek chemiczny, syntetyczny opioidowy lek przeciwbólowy z grupy morfinanów. Stosowany w lecznictwie w postaci soli kwas winowego. (pl)
dbo:atcPrefix
  • N02
dbo:atcSuffix
  • AF01
dbo:casNumber
  • 42408-82-2
dbo:chEBI
  • 3242
dbo:drugbank
  • DB00611
dbo:fdaUniiCode
  • QV897JC36D
dbo:iupacName
  • (4bR,8aR,9S)-11-(cyclobutylmethyl)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-3,8a-diol (en)
dbo:pubchem
  • 5361092
dbo:thumbnail
dbo:wikiPageExternalLink
dbo:wikiPageID
  • 4497628 (xsd:integer)
dbo:wikiPageRevisionID
  • 744304035 (xsd:integer)
dbp:alt
  • Ball-and-stick model
  • Structural formula
dbp:bioavailability
  • Nasal: 60-70%
dbp:c
  • 21 (xsd:integer)
dbp:chembl
  • 33986 (xsd:integer)
dbp:chemspiderid
  • 16735714 (xsd:integer)
dbp:eliminationHalfLife
  • -25200.0
dbp:excretion
  • Biliary, 11-14%
  • Fecal, 15%
  • Renal, 75%
dbp:h
  • 29 (xsd:integer)
dbp:image
  • Butorphanol molecule ball.png
dbp:iupharLigand
  • 7591 (xsd:integer)
dbp:kegg
  • D00837
dbp:legalAu
  • S8
dbp:legalCa
  • Schedule IV
dbp:legalUs
  • Schedule IV
dbp:medlineplus
  • a682667
dbp:metabolism
  • Hepatic hydroxylated & glucuronidated
dbp:molecularWeight
  • 327.473000 (xsd:double)
dbp:n
  • 1 (xsd:integer)
dbp:o
  • 2 (xsd:integer)
dbp:pregnancyCategory
  • C/D
dbp:routesOfAdministration
  • IV, intranasal, oral
dbp:smiles
  • OC1=CC2=CC[C@H]3NCC5CCC5
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • IFKLAQQSCNILHL-QHAWAJNXSA-N
dbp:tradename
  • Stadol
dbp:verifiedfields
  • changed
dbp:verifiedrevid
  • 459988204 (xsd:integer)
dbp:watchedfields
  • changed
dbp:width
  • 210 (xsd:integer)
  • 240 (xsd:integer)
dct:subject
rdf:type
rdfs:comment
  • بوتورفانول Butorphanol أو Stadol هو مسكن أفيوني اصطناعي, مشابه كيميائيا لليفورفانول levorphanol. (AAN، BAN، INN و USAN) هو مورفين - نوع اصطناعي من الافيونيات المسكنات تم تطويره من قبل بريستول مايرز فعال في تسكين الألم عند النساء أكثر من الرجال. يُؤَثِّر الدَّواءُ في مَراكِز معيَّنة في الجهاز العصبي المركزي لتخفيف الألم، حيث يتَّحِد مع مستقبلات الأفيون في الدِّماغ لمنع انتقال إشارات الألم. هو من المُنَبِّهات الأفيونيَّة الجزئيَّة Opiate Partial Agonists. يفيد في تَسكين الألم، مثل المورفين. (ar)
  • Le butorphanol est un dérivé agoniste-antagoniste opioïde ayant une activité μ-antagoniste, κ-agoniste et σ-agoniste, contrairement à la plupart des opiacés, lui permettant d'être utilisé comme analgésique. (fr)
  • Butorphanol ist ein stark wirksames Schmerzmittel (Analgetikum) aus der Gruppe der Opioide. Es wirkt als ein Agonist am κ- und δ-Opioid-Rezeptor und ein Antagonist am μ−Opioid-Rezeptor. Butorphanol wird als Tierarzneimittel verwendet. (de)
  • Il Butorfanolo è un analgesico oppiaceo di origine sintetica ideato da Bristol-Myers. Il suo nome commerciale inizialmente fu “Stadol”, ma recentemente è disponibile nelle sue formulazioni generiche prodotte da diverse case farmaceutiche. Il Butorfanolo è strutturalmente molto simile al Levorfanolo. Chimicamente il Butorfanolo è disponibile sotto forma di sale di tartrato e può essere presente in spray intranasale, in compresse oppure può essere iniettabile. Le compresse vengono utilizzate in medicina veterinaria, per cani e gatti. Questa molecola fa parte della categoria degli stupefacenti dal 1961 e negli Stati Uniti è una sostanza facente parte dell'allegato 4 dal 31 ottobre 1997. (it)
  • Butorfanol is een synthetisch opioïde met μ-antagoniste, κ-agoniste en σ-agoniste activiteiten. (nl)
  • Буторфанол — лекарственное средство, опиоидный анальгетик. (ru)
  • Butorfanol é um fármaco agonista parcial utilizado pela medicina humana e pela medicina veterinária como analgésico opioide, é utilizado também para promover a analgesia em gatos. (pt)
  • Butorfanol (łac. Butorphanolum) – organiczny związek chemiczny, syntetyczny opioidowy lek przeciwbólowy z grupy morfinanów. Stosowany w lecznictwie w postaci soli kwas winowego. (pl)
  • Butorphanol (AAN, BAN, INN and USAN) is a morphinan-type synthetic opioid analgesic developed by Bristol-Myers. Brand name Stadol was recently discontinued by the manufacturer. It is now only available in its generic formulations, manufactured by Novex, Mylan, Apotex and Ben Venue Laboratories. Butorphanol is most closely structurally related to levorphanol. Butorphanol is available as the tartrate salt in injectable, tablet, and intranasal spray formulations. The tablet form is only used in dogs and cats due to low bioavailability in humans. (en)
rdfs:label
  • بوتورفانول (ar)
  • Butorphanol (de)
  • Butorphanol (en)
  • Butorphanol (fr)
  • Butorfanolo (it)
  • Butorfanol (nl)
  • Butorfanol (pl)
  • Butorfanol (pt)
  • Буторфанол (ru)
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