Bartolomeo Gosio (17 March 1863 – 13 April 1944) was an Italian medical scientist. He discovered a toxic fume, eponymously named "Gosio gas", which is produced by microorganisms, that killed many people. He identified the chemical nature of the gas as an arsenic compound (arsine), but incorrectly named it as diethylarsine. He also discovered an antibacterial compound called mycophenolic acid from the mould Penicillium brevicompactum. He demonstrated that the novel compound was effective against the deadly anthrax bacterium, Bacillus anthracis. This was the first antibiotic compound isolated in pure and crystallised form. Though the original compound was abandoned in clinical practice due to its adverse effects, its chemical derivative mycophenolate mofetil became the drug of choice as an i

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dbo:abstract
  • Bartolomeo Gosio (* 17. März 1863 in Magliano Alfieri, Königreich Italien; † 13. April 1944 in Rom) war ein italienischer Arzt und Mikrobiologe. In einem Schimmelpilz entdeckte er ein Stoffwechselprodukt mit antibiotischen Eigenschaften und stellte es rein dar. Diese Mycophenolsäure war das erste, gut charakterisierte Antibiotikum der Geschichte. Außerdem zeigte er, dass manche Schimmelpilze anorganische Formen des Arsens in ein giftiges, organisches Gas umwandeln können. In der Folge wurden Tapeten, die mit arsenhaltigen Farben bedruckt waren, als Gesundheitsgefahr erkannt. Als Direktor des Wissenschaftlichen Labors des Öffentlichen Gesundheitsdiensts in Rom leistete er ab 1899 wichtige Beiträge zur Malaria-Kontrolle in Italien. (de)
  • In una specie di muffa, scoprì una metabolita con delle proprietà antibiotiche, e la purificò. L'acido micofenolico (MPA) è stato il primo antibiotico della storia a essere stato ben caratterizzato. Egli anche dimostrò che alcune muffe possono trasformare forme inorganiche di arsenico in un gas organico tossico (Gas di Gosio). Come risultato, le carte da parato che sono state stampate con inchiostri contenenti arsenico sono stati riconosciute come un rischio per la salute. Fu Direttore del Laboratorio della Sanità Pubblica di Roma, istituito nel 1887 da Francesco Crispi, dal 1888 al 1899, periodo in cui diede contributi importanti nella lotta contro la malaria in Italia. (it)
  • Bartolomeo Gosio (17 March 1863 – 13 April 1944) was an Italian medical scientist. He discovered a toxic fume, eponymously named "Gosio gas", which is produced by microorganisms, that killed many people. He identified the chemical nature of the gas as an arsenic compound (arsine), but incorrectly named it as diethylarsine. He also discovered an antibacterial compound called mycophenolic acid from the mould Penicillium brevicompactum. He demonstrated that the novel compound was effective against the deadly anthrax bacterium, Bacillus anthracis. This was the first antibiotic compound isolated in pure and crystallised form. Though the original compound was abandoned in clinical practice due to its adverse effects, its chemical derivative mycophenolate mofetil became the drug of choice as an immunosuppressant in kidney, heart, and liver transplantations. (en)
dbo:almaMater
dbo:birthDate
  • 1863-03-17 (xsd:date)
  • 1863-3-17
dbo:birthPlace
dbo:deathDate
  • 1944-04-13 (xsd:date)
  • 1944-4-13
dbo:deathPlace
dbo:field
dbo:knownFor
dbo:wikiPageID
  • 47314697 (xsd:integer)
dbo:wikiPageRevisionID
  • 732644286 (xsd:integer)
dbp:nationality
  • Italian
dbp:workplaces
  • Istituto Superiore di Sanità
  • Laboratori Scientifici della Direzione di Sanità
dct:description
  • Italian physician, microbiologist and biochemist (en)
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • Bartolomeo Gosio (* 17. März 1863 in Magliano Alfieri, Königreich Italien; † 13. April 1944 in Rom) war ein italienischer Arzt und Mikrobiologe. In einem Schimmelpilz entdeckte er ein Stoffwechselprodukt mit antibiotischen Eigenschaften und stellte es rein dar. Diese Mycophenolsäure war das erste, gut charakterisierte Antibiotikum der Geschichte. Außerdem zeigte er, dass manche Schimmelpilze anorganische Formen des Arsens in ein giftiges, organisches Gas umwandeln können. In der Folge wurden Tapeten, die mit arsenhaltigen Farben bedruckt waren, als Gesundheitsgefahr erkannt. Als Direktor des Wissenschaftlichen Labors des Öffentlichen Gesundheitsdiensts in Rom leistete er ab 1899 wichtige Beiträge zur Malaria-Kontrolle in Italien. (de)
  • In una specie di muffa, scoprì una metabolita con delle proprietà antibiotiche, e la purificò. L'acido micofenolico (MPA) è stato il primo antibiotico della storia a essere stato ben caratterizzato. Egli anche dimostrò che alcune muffe possono trasformare forme inorganiche di arsenico in un gas organico tossico (Gas di Gosio). Come risultato, le carte da parato che sono state stampate con inchiostri contenenti arsenico sono stati riconosciute come un rischio per la salute. Fu Direttore del Laboratorio della Sanità Pubblica di Roma, istituito nel 1887 da Francesco Crispi, dal 1888 al 1899, periodo in cui diede contributi importanti nella lotta contro la malaria in Italia. (it)
  • Bartolomeo Gosio (17 March 1863 – 13 April 1944) was an Italian medical scientist. He discovered a toxic fume, eponymously named "Gosio gas", which is produced by microorganisms, that killed many people. He identified the chemical nature of the gas as an arsenic compound (arsine), but incorrectly named it as diethylarsine. He also discovered an antibacterial compound called mycophenolic acid from the mould Penicillium brevicompactum. He demonstrated that the novel compound was effective against the deadly anthrax bacterium, Bacillus anthracis. This was the first antibiotic compound isolated in pure and crystallised form. Though the original compound was abandoned in clinical practice due to its adverse effects, its chemical derivative mycophenolate mofetil became the drug of choice as an i (en)
rdfs:label
  • Bartolomeo Gosio (de)
  • Bartolomeo Gosio (it)
  • Bartolomeo Gosio (en)
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foaf:gender
  • male (en)
foaf:givenName
  • Bartolomeo (en)
foaf:isPrimaryTopicOf
foaf:name
  • Bartolomeo Gosio (en)
foaf:surname
  • Gosio (en)
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