Alan R. Saltiel was the Mary Sue Coleman Director of the Life Sciences Institute at the University of Michigan; a professor at the Division of Molecular Medicine and Genetics at the University of Michigan Medical School; a faculty member at the Michigan Diabetes Research and Training Center; and John Jacob Abel Professor of Life Sciences, Department of Molecular and Integrative Physiology; a member of the Steering Committee Member at the Center for Advancing Research & Solutions for Society. He served as the Director of the Life Sciences Institute from 2001 to 2015. He was also a John Jacob Abel Collegiate Professor of the Life Sciences at the Department of Molecular & Integrative Physiology at the UM Medical School. He holds an AB from Duke University (1975) and a Ph.D. from the Universit

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dbo:abstract
  • Alan Robert Saltiel (* 29. November 1953 in New Brunswick, New Jersey) ist ein US-amerikanischer Biochemiker, der sich vor allem mit Diabetes mellitus und dem Insulin-System beschäftigt. Saltiel studierte an der Duke University (Bachelor-Abschluss 1975) und wurde 1980 an der University of North Carolina in Biochemie promoviert. Danach war er bis 1984 Forscher beim Pharmakonzern Burroughs-Wellcome (bei Pedro Cuatrecasas) und 1984 bis 1990 Assistant Professor an der Rockefeller University. Von 1990 bis 1996 war er Leiter der Abteilung Signal Transduction bei der Parke-Davis Pharmaceutical Research Division von Warner-Lambert und 1996 bis 2000 Leiter der Abteilung Zellbiologie. Seit 2001 ist er Direktor des Life Sciences Institute der University of Michigan und Professor an der Medical School der University of Michigan. Er untersuchte die unmittelbaren Mechanismen der Zellreaktion und Signalwege nach dem Andocken von Insulin, aber auch EGF und Nervenwachstumsfaktor an die Zelle. Insbesondere interessiert er sich für mögliche Fehlfunktionen im Signalweg von Insulin, die Diabetes auslösen können. Zum Beispiel entdeckte er mit seiner Gruppe neben dem PI-3-Kinase Signalweg einen weiteren über das SH2-Adapterprotein APS (siehe Insulinrezeptor). Sie identifizierten auch verschiedene am Signalweg beteiligte G-Proteine (TC 10). Er untersuchte als möglichen Mechanismus der Ausbildung von Diabetes bei Übergewicht (Adiposis) die Rolle von speziellen Makrophagen im Fettgewebe (Adipose tissue macrophages, ATM), ausgehend von der Überlegung, dass Fettleibigkeit einen Zustand latenter Entzündung (auf niedrigem Niveau) im Körper verursacht. Saltiel erhielt den Rosalyn Yalow Research and Development Award der American Diabetes Association und 1990 den John J. Abel Award. Er ist seit 1981 verheiratet und hat drei Kinder. (de)
  • Alan R. Saltiel was the Mary Sue Coleman Director of the Life Sciences Institute at the University of Michigan; a professor at the Division of Molecular Medicine and Genetics at the University of Michigan Medical School; a faculty member at the Michigan Diabetes Research and Training Center; and John Jacob Abel Professor of Life Sciences, Department of Molecular and Integrative Physiology; a member of the Steering Committee Member at the Center for Advancing Research & Solutions for Society. He served as the Director of the Life Sciences Institute from 2001 to 2015. He was also a John Jacob Abel Collegiate Professor of the Life Sciences at the Department of Molecular & Integrative Physiology at the UM Medical School. He holds an AB from Duke University (1975) and a Ph.D. from the University of North Carolina (1980). During his doctorate studies in biochemistry at the University of North Carolina, Saltiel worked on thyroid-stimulating hormone and its relationship to thyroid cancer. As a post-doctoral fellow under Pedro Cuatrecasas in the Wellcome Research Labs, he began investigating insulin. He was Distinguished Research Fellow and Senior Director of the Department of Cell Biology at Parke-Davis Pharmaceutical Research Division (now Pfizer Global Research). In addition to having published more than 260 research papers, Saltiel holds 16 patents and has extensive experience with the FDA's testing and approval process for new drugs. Saltiel's lab researches signaling pathways in insulin action. Such research is aimed at identifying the various ways in which problems with the insulin signaling pathway trigger diabetes. Researchers in the lab have also uncovered new hormone signaling pathways and the role that proteins and genes play in this process. These discoveries may reveal how the insulin-glucose balance necessary for the survival of the cell is lost due to obesity in those with diabetes. (en)
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  • 1953-11-29 (xsd:date)
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  • American academic (en)
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  • Alan Robert Saltiel (* 29. November 1953 in New Brunswick, New Jersey) ist ein US-amerikanischer Biochemiker, der sich vor allem mit Diabetes mellitus und dem Insulin-System beschäftigt. Saltiel studierte an der Duke University (Bachelor-Abschluss 1975) und wurde 1980 an der University of North Carolina in Biochemie promoviert. Danach war er bis 1984 Forscher beim Pharmakonzern Burroughs-Wellcome (bei Pedro Cuatrecasas) und 1984 bis 1990 Assistant Professor an der Rockefeller University. Von 1990 bis 1996 war er Leiter der Abteilung Signal Transduction bei der Parke-Davis Pharmaceutical Research Division von Warner-Lambert und 1996 bis 2000 Leiter der Abteilung Zellbiologie. Seit 2001 ist er Direktor des Life Sciences Institute der University of Michigan und Professor an der Medical School (de)
  • Alan R. Saltiel was the Mary Sue Coleman Director of the Life Sciences Institute at the University of Michigan; a professor at the Division of Molecular Medicine and Genetics at the University of Michigan Medical School; a faculty member at the Michigan Diabetes Research and Training Center; and John Jacob Abel Professor of Life Sciences, Department of Molecular and Integrative Physiology; a member of the Steering Committee Member at the Center for Advancing Research & Solutions for Society. He served as the Director of the Life Sciences Institute from 2001 to 2015. He was also a John Jacob Abel Collegiate Professor of the Life Sciences at the Department of Molecular & Integrative Physiology at the UM Medical School. He holds an AB from Duke University (1975) and a Ph.D. from the Universit (en)
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  • Alan R. Saltiel (de)
  • Alan R. Saltiel (en)
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