Adrafinil (CRL-40028, Olmifon) is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time. Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in nearly identical pharmacological effects.

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  • Adrafinil (CRL-40028, Olmifon) is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time. Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in nearly identical pharmacological effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45–60 minutes when taken orally on an empty stomach. Adrafinil does not currently have FDA approval and is thus unregulated in the United States, although it is used in France and elsewhere in Europe. The drug is marketed under the brand name Olmifon as a racemate with a stereogenic centre at the sulfur atom.
  • Adrafinil ist ein Arzneistoff zur Behandlung von Schlafstörungen wie z. B. der Narkolepsie. Die Substanz gehört zu einer Gruppe psychostimulierender Medikamente, die sich in der Molekülstruktur von den Amphetamin-artigen Stimulanzien deutlich unterscheidet. Adrafinil ist ein Prodrug, das erst durch Metabolisierung zu Modafinil wirksam wird. In seiner Wirkung entspricht es Modafinil. Jedoch setzt aufgrund der Metabolisierung die Wirkung verzögert ein. Adrafinil wird in Frankreich unter dem Produktnamen Olmifon vertrieben. Es ist wie Modafinil eine verbotene Dopingsubstanz.
  • Adrafinil (ook bekend als Olmifon) is een centraal zenuwstelsel stimulant tegen excessieve slaperigheid, gericht op het bevorderen van waakzaamheid en alertheid. Het middel is ontwikkeld door het Amerikaanse Cephalon en wordt geproduceerd onder de merknaam Olmifon.
  • O adrafinila é um fármaco estimulante do sistema nervoso central empregado em aliviar a insónia excessiva e as distrações em pacientes maiores de idade. Também a usam em pessoas que podem ter fadiga ou trabalhadores noturnos ou aqueles que precisam estar em alerta por compridos períodos de tempo. Os efeitos do consumo mostram-se entre os 45-60 minutos quando se tomam oralmente num estômago vazio. Não está aprovada nos E.U. A, porém usa-se na França e em outros lugares da Europa. Foi criada pela companhia farmacêutica francesa Lafon em 2001.
  • L'adrafinil est un stimulant,découvert à la fin des années 1970 par les laboratoires Lafon. Aujourd'hui commercialisé par les Laboratoires Céphalon avec la spécialité Omifon, délivrée sur prescription uniquement. Il est utilisé pour traiter les troubles de la vigilance et certains symptômes neurologiques chez le sujet âgé.
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  • Adrafinil (ook bekend als Olmifon) is een centraal zenuwstelsel stimulant tegen excessieve slaperigheid, gericht op het bevorderen van waakzaamheid en alertheid. Het middel is ontwikkeld door het Amerikaanse Cephalon en wordt geproduceerd onder de merknaam Olmifon.
  • Adrafinil ist ein Arzneistoff zur Behandlung von Schlafstörungen wie z. B. der Narkolepsie. Die Substanz gehört zu einer Gruppe psychostimulierender Medikamente, die sich in der Molekülstruktur von den Amphetamin-artigen Stimulanzien deutlich unterscheidet. Adrafinil ist ein Prodrug, das erst durch Metabolisierung zu Modafinil wirksam wird. In seiner Wirkung entspricht es Modafinil. Jedoch setzt aufgrund der Metabolisierung die Wirkung verzögert ein.
  • Adrafinil (CRL-40028, Olmifon) is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time. Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in nearly identical pharmacological effects.
  • O adrafinila é um fármaco estimulante do sistema nervoso central empregado em aliviar a insónia excessiva e as distrações em pacientes maiores de idade. Também a usam em pessoas que podem ter fadiga ou trabalhadores noturnos ou aqueles que precisam estar em alerta por compridos períodos de tempo. Os efeitos do consumo mostram-se entre os 45-60 minutos quando se tomam oralmente num estômago vazio. Não está aprovada nos E.U. A, porém usa-se na França e em outros lugares da Europa.
  • L'adrafinil est un stimulant,découvert à la fin des années 1970 par les laboratoires Lafon. Aujourd'hui commercialisé par les Laboratoires Céphalon avec la spécialité Omifon, délivrée sur prescription uniquement. Il est utilisé pour traiter les troubles de la vigilance et certains symptômes neurologiques chez le sujet âgé.
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  • Adrafinil
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