The ACTH receptor is a type of melanocortin receptor (type 2), properly known as MC2, which is specific for ACTH. It is found in the zona fasciculata of the human adrenal cortex. Binding of the receptor by ACTH stimulates the production of cortisol. (By contrast, aldosterone production from the zona glomerulosa is stimulated primarily by angiotensin II. ) The ACTH receptor uses cAMP as a secondary messenger.

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dbpedia-owl:abstract
  • Der Melanocortinrezeptor 2 wird in der Nebennierenrinde exprimiert und vermittelt dort die Wirkungen des ACTH. Es handelt sich um einen G-Protein gekoppelten Rezeptor aus der Familie der Melanocortinrezeptoren.
  • The ACTH receptor is a type of melanocortin receptor (type 2), properly known as MC2, which is specific for ACTH. It is found in the zona fasciculata of the human adrenal cortex. Binding of the receptor by ACTH stimulates the production of cortisol. (By contrast, aldosterone production from the zona glomerulosa is stimulated primarily by angiotensin II. ) The ACTH receptor uses cAMP as a secondary messenger. Mutations in this receptor cause familial glucocorticoid deficiency type 1, in which patients have high levels of serum ACTH and low levels of cortisol.
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  • 4158
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  • Der Melanocortinrezeptor 2 wird in der Nebennierenrinde exprimiert und vermittelt dort die Wirkungen des ACTH. Es handelt sich um einen G-Protein gekoppelten Rezeptor aus der Familie der Melanocortinrezeptoren.
  • The ACTH receptor is a type of melanocortin receptor (type 2), properly known as MC2, which is specific for ACTH. It is found in the zona fasciculata of the human adrenal cortex. Binding of the receptor by ACTH stimulates the production of cortisol. (By contrast, aldosterone production from the zona glomerulosa is stimulated primarily by angiotensin II. ) The ACTH receptor uses cAMP as a secondary messenger.
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  • Melanocortin-2-Rezeptor
  • ACTH receptor
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