Whitman Mission National Historic Site is a United States National Historic Site located just west of Walla Walla, Washington, at the site of the former Whitman Mission at Waiilatpu. On November 29, 1847, Dr. Marcus Whitman, his wife Narcissa Whitman, and 11 others were slain by Native Americans of the Cayuse. The site commemorates the Whitmans, their role in establishing the Oregon Trail, and the challenges encountered when two cultures meet.