Mitrephora polypyrena is a species of plant in the family Annonaceae. It is native to Java, the Lesser Sunda Islands, and Myanmar. Carl Ludwig Blume, the German botanist who first formally described the species using the basionym Uvaria polypyrena, named it after the many stones or seeds (Latinized forms of Greek πολυ-, poly-, and πυρην, pyren) in its fruit.