Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis. The existence of a receptor for transferrin iron uptake had been recognized over half a century back. Earlier two transferrin receptors in humans, transferrin receptor 1 and transferrin receptor 2 had been characterized and until recently cellular iron uptake was believed to occur chiefly via these two well documented transferrin receptors. Both these receptors are transmembrane glycoproteins. TfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and
| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:label
| - Transferinový receptor (cs)
- Récepteur de la transferrine (fr)
- Transferrin receptor (en)
- 转铁蛋白受体 (zh)
|
| rdfs:comment
| - Transferinový receptor (TfR) je transportní protein pro transferin, který zajišťuje přenos železa do buňky dle intracelulární koncentrace železa. Vzniká transferin-železo komplex pomocí receptorem zprostředkované endocytózy. . Receptory jsou transmembránové glykoproteiny. Zatímco TfR1 má všude vysokou afinitu k železu, exprese TfR2 je omezena na určité typy buněk a není ovlivněna intracelulární koncentraci železa. TfR2 se váže na transferin s 25–30krát nižší afinitu než TfR1. Ačkoli TfR1 zprostředkované vychytávání železa je hlavní cestou pro získání železa ve většině buněk zejména v vývojových erytrocytů, mechanismus vychytávání se liší v závislosti na typu buněk. . (cs)
- Le récepteur de la transferrine (ou TfR pour Transferrin Receptor) est un dimère situé à la surface des cellules permettant l'endocytose de la transferrine. Chez l'humain, ce récepteur est exprimé dans tous les types cellulaires. (fr)
- 運鐵蛋白受體（英語：transferrin receptor），又稱運鐵蛋白受體，是運鐵蛋白的載體蛋白，每個分子含有兩個次單元（subunit），可結合兩個運鐵蛋白，再催化胞飲作用將它運入細胞中。 (zh)
- Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis. The existence of a receptor for transferrin iron uptake had been recognized over half a century back. Earlier two transferrin receptors in humans, transferrin receptor 1 and transferrin receptor 2 had been characterized and until recently cellular iron uptake was believed to occur chiefly via these two well documented transferrin receptors. Both these receptors are transmembrane glycoproteins. TfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and (en)
|
| foaf:name
| - Transferrin receptor 1 (en)
- Transferrin receptor 2 (en)
|
| name
| |
| foaf:depiction
| |
| dcterms:subject
| |
| Wikipage page ID
| |
| Wikipage revision ID
| |
| Link from a Wikipage to another Wikipage
| |
| Link from a Wikipage to an external page
| |
| sameAs
| |
| dbp:wikiPageUsesTemplate
| |
| thumbnail
| |
| OMIM
| |
| AltSymbols
| - CD71, TFR1 (en)
- HFE3, TFRC2 (en)
|
| caption
| - Transferrin receptor 1, dimer, Human (en)
|
| symbol
| |
| UniProt
| |
| width
| |
| has abstract
| - Transferinový receptor (TfR) je transportní protein pro transferin, který zajišťuje přenos železa do buňky dle intracelulární koncentrace železa. Vzniká transferin-železo komplex pomocí receptorem zprostředkované endocytózy. . Receptory jsou transmembránové glykoproteiny. Zatímco TfR1 má všude vysokou afinitu k železu, exprese TfR2 je omezena na určité typy buněk a není ovlivněna intracelulární koncentraci železa. TfR2 se váže na transferin s 25–30krát nižší afinitu než TfR1. Ačkoli TfR1 zprostředkované vychytávání železa je hlavní cestou pro získání železa ve většině buněk zejména v vývojových erytrocytů, mechanismus vychytávání se liší v závislosti na typu buněk. . (cs)
- Le récepteur de la transferrine (ou TfR pour Transferrin Receptor) est un dimère situé à la surface des cellules permettant l'endocytose de la transferrine. Chez l'humain, ce récepteur est exprimé dans tous les types cellulaires. (fr)
- Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis. The existence of a receptor for transferrin iron uptake had been recognized over half a century back. Earlier two transferrin receptors in humans, transferrin receptor 1 and transferrin receptor 2 had been characterized and until recently cellular iron uptake was believed to occur chiefly via these two well documented transferrin receptors. Both these receptors are transmembrane glycoproteins. TfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and is unaffected by intracellular iron concentrations. TfR2 binds to transferrin with a 25-30 fold lower affinity than TfR1. Although TfR1 mediated iron uptake is the major pathway for iron acquisition by most cells and especially developing erythrocytes, several studies have indicated that the uptake mechanism varies depending upon the cell type. It is also reported that Tf uptake exists independent of these TfRs although the mechanisms are not well characterized. The multifunctional glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH, EC 1.2.1.12) has been shown to utilize post translational modifications to exhibit higher order moonlighting behavior wherein it switches its function as a holo or apo transferrin receptor leading to either iron delivery or iron export respectively. (en)
- 運鐵蛋白受體（英語：transferrin receptor），又稱運鐵蛋白受體，是運鐵蛋白的載體蛋白，每個分子含有兩個次單元（subunit），可結合兩個運鐵蛋白，再催化胞飲作用將它運入細胞中。 (zh)
|
| Arm
| |
| band
| |
| Chromosome
| |
| EntrezGene
| |
| HGNCid
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)
