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SNARE proteins (an acronym derived from "SNAP (Soluble NSF Attachment Protein) REceptor") are a large protein superfamily consisting of at least 24 members in yeasts and more than 60 members in mammalian cells. The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.

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rdf:type
rdfs:label
  • SNARE (Protein)
  • SNARE (protein)
  • SNARE (proteína)
  • SNARE
  • Proteina SNARE
  • SNARE-eiwit
  • SNARE
  • SNARE
  • SNARE
rdfs:comment
  • SNARE-Komplexe (Engl. Abkürzung für: soluble N-ethylmaleimide-sensitive-factor attachment receptor) sind Proteinkomplexe in Vesikeln von eukaryotischen Zellen. Die Untereinheiten dieser Komplexe werden entsprechend SNARE-Proteine genannt. SNARE-Komplexe katalysieren bei der Fusion von biologischen Membranen den Transport von small molecules, beispielsweise bei einer Exozytose in den synaptischen Spalt.
  • SNARE proteins (an acronym derived from "SNAP (Soluble NSF Attachment Protein) REceptor") are a large protein superfamily consisting of at least 24 members in yeasts and more than 60 members in mammalian cells. The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.
  • As SNAREs (soluble NSF attachment receptor) constituem uma família de proteínas que desempenham um papel central na geração da especificidade do tráfego vesicular e na catálise do processo de fusão. Muitas vesículas transportadoras só se formam se um tipo específico de proteína Rab e SNARE estiverem acopladas à sua membrana, permitindo assim que a vesícula se funda corretamente.
  • SNARE – grupa białek należących do dużej rodziny białek transbłonowych. Biorą one udział w rozpoznawaniu i fuzji pęcherzyków z błoną komórkową. Białka SNARE można podzielić na dwie grupy: * v-SNARE – obecne na pęcherzykach * t-SNARE – obecne po cytoplazmatycznej stronie błony docelowej Toksyny wytwarzane przez bakterie z rodzaju Clostridium (toksyna tężcowa, toksyna botulinowa) są endoproteazami, które powodują rozkład białek kompleksu SNARE. Prowadzi to do zahamowania przewodnictwa na poziomie synaptycznym.
  • SNARE (от англ. soluble NSF attachment receptor) — большая группа белков, осуществляющих слияние внутриклеточных транспортных везикул с клеточной мембраной (экзоцитоз) или органеллой-мишенью, такой как лизосома. Насчитывается около 60 белков SNARE. Белки группы делятся на две функциональные категории: везикулярные белки (v-SNARE) и белки принимающей органеллы (t-SNARE). Новая структурная классификация подразделяет группу на R-SNARE и Q-SNARE. Наиболее изучены белки, которые выполняют доставку синаптических везикул к пресинаптической мембране и их слияние. Эти белки являются мишенями опасных бактериальных токсинов ботулизма и столбняка.
  • Las proteínas SNARE (acrónimo derivado de su traducción en inglés "SNAP Soluble NSF Attachment Protein REceptor" o Receptor de Proteína de fijación soluble de NSF) son un grupo de grandes proteínas, consta de más de 60 miembros en células de levadura y mamíferos.
  • Le proteine SNARE costituiscono una famiglia di proteine integrali di membrana con più di 35 membri, localizzati in specifici comparti sub-cellulari.Sono dei recettori di SNAP (SNAP= Soluble NSF Attachment Protein dove la sigla NSF indica una ATPasi e significa fattore sensibile alla N-etilmaleimide), da cui l'acronimo SNARE (SNAP REceptor). Benché variabili in dimensione e struttura, tutte le proteine SNARE contengono nel loro dominio citosolico un segmento di circa 70 aminoacidi disposti in eptadi ripetute chiamato motivo SNARE.
  • SNARE-eiwitten (acronym van soluble NSF attachment receptor) zijn een grote superfamilie van eiwitten die bestaat uit meer dan zestig soorten eiwit die voorkomen in gisten en zoogdiercellen. De voornaamste rol van SNARE-eiwitten is om de koppeling en versmelting tussen verschillende membranen en versmelting van cellulaire transportvesikels met het celmembraan of het membraan van een intracellulair compartiment (zoals een lysosoom) mogelijk te maken. Een andere, recenter geformuleerde, classificatie is echter die in R-snares en Q-snares, gebaseerd op structurele kenmerken van de SNARE-eiwitten.
  • Les SNARE (sigle pour l'anglais : Soluble N-éthylmaleimide-sensitive-factor Attachment protein REceptor) sont des protéines majoritairement transmembranaires et forment la superfamille des SNARE dont la structure et la séquence sont particulièrement conservées.
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