About: Phospholipase D

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Phospholipase D (EC 3.1.4.4, lipophosphodiesterase II, lecithinase D, choline phosphatase, PLD; systematic name phosphatidylcholine phosphatidohydrolase) is an enzyme of the phospholipase superfamily that catalyses the following reaction a phosphatidylcholine + H2O = choline + a phosphatidate

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rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Lipid114938907 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:Phospholipid114982681 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatPeripheralMembraneProteins yago:WikicatPhospholipids umbel-rc:ProteinMolecule
rdfs:label	Fosfolipasa D (es) Phospholipase D (fr) Phospholipase D (en) Фосфолипаза D (ru)
rdfs:comment	Fosfolipasa D es una enzima localizada en la membrana plasmática que hidroliza el lípido fosfatidilcolina a ácido fosfatídico (que queda alojado en la membrana) y colina (hidrosoluble y capaz de difundir en el citosol). En humanos hay dos isoformas de esta enzima, y . Relacionada con la transducción de señales, interactúa con proteín kinasas como PKC, y (algunas de las cuales están en la ruta MAPK). (es) Phospholipase D (EC 3.1.4.4, lipophosphodiesterase II, lecithinase D, choline phosphatase, PLD; systematic name phosphatidylcholine phosphatidohydrolase) is an enzyme of the phospholipase superfamily that catalyses the following reaction a phosphatidylcholine + H2O = choline + a phosphatidate (en) Les phospholipases D (PLD) sont des hydrolases associées aux membranes qui catalysent l'hydrolyse des phospholipides, et particulièrement de la phosphatidylcholine, pour générer de la choline et de l'acide phosphatidique. Les mammifères possèdent six isoformes de PLD, notés PLD1 à PLD6. Les PLD1 et PLD2 sont catalytiquement actives, et ce sont les isoformes les mieux décrites à ce jour. Les PLD3, PLD4 et PLD5 ne semblent pas avoir d'activité catalytique et leur fonction est encore discutée. La PLD6 fonctionne en dimère et hydrolyse la cardiolipine mitochondriale. La PLD aurait un rôle important dans de nombreux processus physiologiques : le mûrissement des fruits, le trafic membranaire, la régulation du cytosquelette d'actine, le trafic vésiculaire et la migration cellulaire. Les PLD1 et P (fr) Фосфолипаза D (КФ 3.1.4.4, англ. phospholipase D) — фосфолипаза, гидролизующая фосфодиэфирную связь между остатком фосфолипида и головной группой полярной части. Относится к фосфодиэстеразам также как и фосфолипаза C. Существует 2 изоформы этой фосфолипазы D1 и D2. Обе изоформы специфически расщепляют фосфатидилхолин на фосфатидную кислоту и холин, высвобождая последний в цитоплазму. Изоформы имеют различную внутриклеточную локализацию. Фосфолипаза D1 расположена в аппарате Гольджи, эндосомах, лизосомах и в секреторных гранулах, тогда как фосфолипаза D2 локализуется в липидных рафтах плазматической мембраны. (ru)
foaf:name	phospholipase D1, phosphatidylcholine-specific (en) phospholipase D2 (en)
name	Phospholipase A2 PLD1 Phospholipase D (en) phospholipase D (en)
foaf:depiction
dcterms:subject	EC 3.1.4 Peripheral membrane proteins
Wikipage page ID	5507029 (xsd:integer)
Wikipage revision ID	1116931558 (xsd:integer)
Link from a Wikipage to another Wikipage	Calcium Cancer Cardiolipin Electric charge Elementary reaction Endocytosis Endonuclease Endoplasmic reticulum Endosome Enzyme activator Enzyme assay List of cancer types Membrane Nucleophilic addition Plasma membrane Structural motif Membrane curvature Membrane transport Pathophysiology Breast cancer Allosteric regulation Hormones Regulatory enzymes RhoA Cytoskeleton Cytosol DNA In vitro In vivo Inflammation Inverted repeat Protein aggregation Reaction intermediate Viral protein Protein–protein interaction Sphingosine kinase 1 Neurodegeneration 1-butanol EC 3.1.4 Membrane lipids Chemical affinity Gene duplication Gene expression Phagocytosis Protein purification Nucleophile Proteolysis Phosphatidic acid

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