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Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. Pancreatic elastase 1 is a serine endopeptidase, a specific type of protease that has the amino acid serine at its active site. Although the recommended name is pancreatic elastase, it can also be referred to as elastase-1, pancreatopeptidase, PE, or serine elastase.

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  • Pankreas-Elastase
  • Pancreatic elastase
  • Pancreaselastase
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  • Pankreaselastase wird im Pankreas als inaktives Zymogen (Proelastase) produziert und im Dünndarm durch Spaltung mit Trypsin zu dem Enzym Elastase aktiviert. Das aktive Verdauungsenzym spaltet insbesondere Elastin. Die Pankreaselastase wird unverändert mit dem Stuhl ausgeschieden.
  • Pancreaselastase is een eiwitsplitsend enzym, dat door middel van hydrolysering bijdraagt aan de afbraak en vertering van eiwitten. Het wordt in de alvleesklier aangemaakt als pro-elastase (een Pro-enzym) en vervolgens in de twaalfvingerige darm met behulp van het enzym trypsine omgezet tot elastase.
  • Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. Pancreatic elastase 1 is a serine endopeptidase, a specific type of protease that has the amino acid serine at its active site. Although the recommended name is pancreatic elastase, it can also be referred to as elastase-1, pancreatopeptidase, PE, or serine elastase.
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foaf:name
  • Pancreatic elastase
  • Pancreatic elastase II
  • Pancreatic endopeptidase E
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  • Pankreaselastase wird im Pankreas als inaktives Zymogen (Proelastase) produziert und im Dünndarm durch Spaltung mit Trypsin zu dem Enzym Elastase aktiviert. Das aktive Verdauungsenzym spaltet insbesondere Elastin. Die Pankreaselastase wird unverändert mit dem Stuhl ausgeschieden.
  • Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. Pancreatic elastase 1 is a serine endopeptidase, a specific type of protease that has the amino acid serine at its active site. Although the recommended name is pancreatic elastase, it can also be referred to as elastase-1, pancreatopeptidase, PE, or serine elastase. The first isozyme, pancreatic elastase 1, was initially thought to be expressed in the pancreas. However it was later discovered that it was the only chymotrypsin-like elastase that was not expressed in the pancreas. In fact, pancreatic elastase is expressed in basal layers of epidermis (at protein level). Hence pancreatic elastase 1 has been renamed elastase 1 (ELA1) or chymotrypsin-like elastase family, member 1 (CELA1). For a period of time, it was thought that that ELA1 / CELA1 was not transcribed into a protein. However it was later discovered that it was expressed in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B (CELA3B).
  • Pancreaselastase is een eiwitsplitsend enzym, dat door middel van hydrolysering bijdraagt aan de afbraak en vertering van eiwitten. Het wordt in de alvleesklier aangemaakt als pro-elastase (een Pro-enzym) en vervolgens in de twaalfvingerige darm met behulp van het enzym trypsine omgezet tot elastase.
EC number
  • 3.4.21.36
  • 3.4.21.70
  • 3.4.21.71
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