About: One gene–one enzyme hypothesis

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: One gene–one enzyme hypothesis Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Thing, within Data Space : dbpedia.org associated with source document(s)
QRcode icon

http://dbpedia.org/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FOne_gene%E2%80%93one_enzyme_hypothesis

The one gene–one enzyme hypothesis is the idea that genes act through the production of enzymes, with each gene responsible for producing a single enzyme that in turn affects a single step in a metabolic pathway. The concept was proposed by George Beadle and Edward Tatum in an influential 1941 paper on genetic mutations in the mold Neurospora crassa, and subsequently was dubbed the "one gene–one enzyme hypothesis" by their collaborator Norman Horowitz. In 2004, Horowitz reminisced that "these experiments founded the science of what Beadle and Tatum called 'biochemical genetics.' In actuality they proved to be the opening gun in what became molecular genetics and all the developments that have followed from that." The development of the one gene–one enzyme hypothesis is often considered the

Attributes	Values
rdfs:label	فرضية جين واحد إنزيم واحد (ar) Ein-Gen-ein-Enzym-Hypothese (de) Hypothèse un gène - une enzyme (fr) 一遺伝子一酵素説 (ja) 1유전자 1효소설 (ko) One gene–one enzyme hypothesis (en) Hipótese um gene-uma enzima (pt)
rdfs:comment	一遺伝子一酵素説（いちいでんしいちこうそせつ、英語：one gene-one enzyme hypothesis）とは、遺伝子研究の過程で唱えられた仮説で、個々の遺伝子はそれぞれ一つの酵素を指定するものであるとする説である。遺伝子が酵素に関わっているとの見方はそれ以前からもあったが、生物学の分野で広く認められるようになったのはビードルとテイタムによる研究以降である。彼らはアカパンカビの栄養要求株という生理的形質に関する突然変異と、その遺伝について研究することで、この説の根拠を確定した。この説は遺伝子の役割を酵素を通じてタンパク質という特定の物質に結びつけた点で重要である。 (ja) 1유전자 1효소설(一遺傳子一酵素說, 영어: one gene one enzyme theory)은 1941년에 조지 웰스 비들(George Beadle, 1903년 10월 22일 - 1989년 6월 9일)과 에드워드 로리 테이텀(Edward Tatum, 1909년 12월 14일 - 1975년 11월 5일)이 발표한 붉은빵곰팡이(곰팡이의 일종)를 이용한 실험을 통해 유전자가 효소의 합성에 관여한다는 이론이다. 이 이론은 유전자가 단백질 합성과 밀접한 관련이 있다는 것이 대한 실마리를 제공하였으며 1유전자 1단백질설, 1유전자 1 폴리펩타이드설로 발전하는데 이바지하였다. (ko) فرضية جين واحد إنزيم واحد هي فكرة أن الجينات تعمل من خلال إنتاج إنزيمات، حيث أن كل جين مسؤول عن إنتاج إنزيم واحد وهو ما يؤثر بدوره على خطوة واحدة في المسار الأيضي. اقترح المفهوم جورج بيدل وإدوارد تاتوم في ورقة مؤثرة عام 1941 عن الطفرات الوراثية في قالب «نيوروسبورا كراسا»، وبعد ذلك أُطلق عليها اسم «فرضية جين واحد إنزيم واحد» من قِبل مساعدهما نورمان هورويتز. في عام 2004 ذكر نورمان هورويتز أن «هذه التجارب أسست العلم الذي أسماه بيدل وتاتوم» علم الوراثة البيوكيميائية". في الواقع فإنهم أثبتوا أنها كانت انطلاقة البدء فيما أصبح يسمى علم الوراثة الجزيئية وجميع التطورات التي تلت ذلك." تطوير فرضية جين واحد إنزيم واحد غالبا ما يعتبر أول نتيجة ملموسة فيما اصطلح على تسميته علم الأحياء الجزيئي. على الرغم من أنها كانت مؤثرة للغاية، فإن الاعتراف بالفرضية جاء سريعا بعد اقتراح زيادة تبسيطها. حتى أن إعادة ا (ar) Unter der Ein-Gen-ein-Enzym-Hypothese versteht man die Hypothese, dass ein Gen die Informationen für die Bildung eines bestimmten Enzyms, also ein katalytisch wirkendes Eiweißmolekül trägt. Bereits 1909 hatte der britischen Arzt Archibald Garrod angeborene Stoffwechselstörungen (englisch inborn errors of metabolism) identifiziert und vermutet, dass etwa im Fall der Alkaptonurie ein Enzymdefekt vorliege, der genetisch fixiert sei. Die Hypothese ein Gen – ein Enzym wurde in den 1940er Jahren von George Beadle und Edward Tatum entwickelt und am Schimmelpilz Neurospora experimentell untermauert. Für diese Arbeiten bekamen sie 1958 den Nobelpreis für Physiologie oder Medizin. Diese Hypothese ist inzwischen nur noch eingeschränkt gültig. (de) The one gene–one enzyme hypothesis is the idea that genes act through the production of enzymes, with each gene responsible for producing a single enzyme that in turn affects a single step in a metabolic pathway. The concept was proposed by George Beadle and Edward Tatum in an influential 1941 paper on genetic mutations in the mold Neurospora crassa, and subsequently was dubbed the "one gene–one enzyme hypothesis" by their collaborator Norman Horowitz. In 2004, Horowitz reminisced that "these experiments founded the science of what Beadle and Tatum called 'biochemical genetics.' In actuality they proved to be the opening gun in what became molecular genetics and all the developments that have followed from that." The development of the one gene–one enzyme hypothesis is often considered the (en) L'hypothèse un gène - une enzyme, est l'idée que les gènes agissent par la production d'enzymes, chaque gène étant responsable de la production d'une enzyme unique qui à son tour affecte une seule étape dans une voie métabolique. Le concept a été proposé par George Beadle et Edward Tatum dans un article fondateur en 1941 sur les mutations génétiques chez le champignon Neurospora crassa, et par la suite a été surnommé l' « hypothèse un gène - une enzyme » par leur collaborateur . Il s'agit certainement du premier résultat significatif dans ce qui allait être appelé la biologie moléculaire. Bien que très influente, l'hypothèse a été reconnue peu de temps après sa proposition comme d'une simplification excessive. Même la reformulation ultérieure « un gène - un polypeptide » est maintenant con (fr) A hipótese um gene-uma enzima é a ideia de que os genes atuam por intermédio da produção de enzimas, com cada gene responsável pela produção de uma única enzima que por seu lado afeta um único passo de uma via metabólica. O conceito foi proposto por George Beadle e Edward Tatum num influente artigo publicado em 1941 sobre mutações genéticas no bolor Neurospora crassa, e subsequentemente denominado como "hipótese um gene-uma enzima" pelo seu colaborador . É muitas vezes considerado o primeiro resultado significativo do que viria a ser conhecido como biologia molecular. Apesar de ter tido uma grande influência, rapidamente foi reconhecido que esta hipótese era uma sobressimplificação. Mesmo a reformulação que se lhe seguiu, denominada "hipótese um gene-um polipéptido", é atualmente considera (pt)
foaf:depiction
dcterms:subject	Obsolete biology theories History of genetics History of biology 1941 in biology
Wikipage page ID	20971660 (xsd:integer)
Wikipage revision ID	1124818615 (xsd:integer)
Link from a Wikipage to another Wikipage	Caltech Proteins Rockefeller Foundation Electrophoresis Mendelian inheritance Boris Ephrussi Alkaptonuria Obsolete biology theories Richard J. Roberts DNA Vernon Ingram Vitamin Max Delbrück Edward Tatum Enzymes Gene Genetics (journal) George Beadle Thomas Hunt Morgan Proceedings of the National Academy of Sciences Chlamydomonas Stanford University Franz Moewus Metabolic pathway Tobacco mosaic virus History of genetics Drosophila melanogaster Adolf Butenandt Amino acid E. coli History of biology Oxford University Press Paper chromatography List of Nobel laureates in Physiology or Medicine George Wells Beadle Harvard University Press Jan Sapp Archibald Garrod 1941 in biology Ascospore Assay Autocatalysis Avery–MacLeod–McCarty experiment Growth medium Edward Lawrie Tatum Metabolic disorder Metabolites Recessive World War II X-ray Yale University Press Norman Horowitz Oversimplification Sickle-cell disease Neurospora crassa Molecular biology Protein Science Spliceosome Norman Horowitz (geneticist) Auxotroph Phillip Sharp Military funding of science Nucleoproteins Multimeric protein dbr:Carl_C._Lingegren dbr:Rowland_H._Davis
sameAs	One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis One gene–one enzyme hypothesis
dbp:wikiPageUsesTemplate	dbt:Cite_book

Faceted Search & Find service v1.17_git139 as of Feb 29 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (62 GB total memory, 45 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software