About: Neuropeptide VF precursor

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Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is encoded by the NPVF (or RPFP) gene. The NPVF gene, and thus the propeptide, are expressed in neurons in the mediobasal hypothalamus. The propeptide is cleaved to form three other peptides, which are:

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein
rdfs:label	Neuropeptide VF precursor (en) NPVF (uk)
rdfs:comment	NPVF (англ. Neuropeptide VF precursor) – білок, який кодується однойменним геном, розташованим у людей на 7-й хромосомі. Довжина поліпептидного ланцюга білка становить 196 амінокислот, а молекулярна маса — 22 309. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Секретований назовні. (uk) Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is encoded by the NPVF (or RPFP) gene. The NPVF gene, and thus the propeptide, are expressed in neurons in the mediobasal hypothalamus. The propeptide is cleaved to form three other peptides, which are: (en)
foaf:name	Neuropeptide VF precursor (en)
name	Neuropeptide VF precursor (en)
dcterms:subject	Hormones of the hypothalamus-pituitary-gonad axis Sex hormones Precursor proteins Peptide hormones Animal reproductive system Neuropeptides
Wikipage page ID	48227329 (xsd:integer)
Wikipage revision ID	1073190223 (xsd:integer)
Link from a Wikipage to another Wikipage	Bird Hypothalamus Peptide EC50 Neuropeptide Hormones of the hypothalamus-pituitary-gonad axis Sex hormones Neuron Gene Mammal Receptor antagonist Agonist Precursor proteins FMRFamide Gonadotropin Gonadotropin-inhibitory hormone Gonadotropin-releasing hormone Gonadotropin release inhibitor Peptide hormones Animal reproductive system Neuropeptides Biological activity Kisspeptin IC50 Neuropeptide FF Propeptide RFamide-related peptide NPFF1 receptor NPFF2 receptor NPFF receptor dbr:Neuropeptide_SF dbr:Neuropeptide_VF dbr:RF9_(drug) dbr:RFRP-2
sameAs	Neuropeptide VF precursor Neuropeptide VF precursor Neuropeptide VF precursor Neuropeptide VF precursor Neuropeptide VF precursor Neuropeptide VF precursor
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Hormones dbt:Protein-stub dbt:Reflist dbt:Infobox_protein dbt:Gene-stub dbt:Neuropeptides
AltSymbols	RPFP (en)
symbol	NPVF (en)
has abstract	Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is encoded by the NPVF (or RPFP) gene. The NPVF gene, and thus the propeptide, are expressed in neurons in the mediobasal hypothalamus. The propeptide is cleaved to form three other peptides, which are: * (NPSF) (RFRP-1) – agonist of the NPFF1 and NPFF2 receptors (EC50 = 29 nM and 0.0011 nM, respectively) * – does not bind to either of the NPFF receptors; no known biological activity * (NPVF) (RFRP-3) – agonist of the NPFF1 receptor (IC50 = 0.7 nM) NPSF and NPVF, originally referred to as the RFamide-related peptides RFRP-1 and RFRP-3, respectively, are the mammalian homologs of the avian neuropeptide gonadotropin-inhibitory hormone (GnIH). The mammalian NPVF and avian GnIH genes, along with their aforementioned peptide products, were discovered concurrently in 2000. Similarly to the avian GnIH neuropeptide, NPSF and NPVF have been found to potently inhibit gonadotropin secretion. Moreover, a potent and selective antagonist of the NPFF receptors, , has been reported to possess "very strong" gonadotropin-releasing effects in vivo in male and female mice. (en) NPVF (англ. Neuropeptide VF precursor) – білок, який кодується однойменним геном, розташованим у людей на 7-й хромосомі. Довжина поліпептидного ланцюга білка становить 196 амінокислот, а молекулярна маса — 22 309. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Секретований назовні. (uk)
HGNCid	13782 (xsd:integer)
gold:hypernym	Propeptide
HGNCid	13782
prov:wasDerivedFrom	wikipedia-en:Neuropeptide_VF_precursor?oldid=1073190223&ns=0
page length (characters) of wiki page	5498 (xsd:nonNegativeInteger)
Symbol	NPVF RPFP
foaf:isPrimaryTopicOf	wikipedia-en:Neuropeptide_VF_precursor
is Link from a Wikipage to another Wikipage of	Pro-FMRFamide-related neuropeptide VF RFamide peptide family NPVF FMRFamide Gonadotropin release inhibitor Kisspeptin Neuropeptide FF RF-amide-related peptide precursor RFRP precursor RF amide-related peptide precursor RFamide-related peptide precursor NPVF precursor
is Wikipage redirect of	Pro-FMRFamide-related neuropeptide VF NPVF RF-amide-related peptide precursor RFRP precursor RF amide-related peptide precursor RFamide-related peptide precursor NPVF precursor
is foaf:primaryTopic of	wikipedia-en:Neuropeptide_VF_precursor

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