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Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium.

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  • Laudanosin
  • Laudanosina
  • Laudanosine
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  • La laudanosina es un alcaloide benciltetrahidroisoquinolínico del opio. La laudanosina disminuye el umbral de convulsiones, por lo que puede inducir convulsiones si están presentes en concentraciones suficientes de umbral. Fue aislado por primera vez en 1871. LA hidrogenación parcial de la laudanosina produce la papaverina. Se ha encontrado que este alcaloide interactúa con los receptores GABA, receptores opioidesy receptores nicotínicospero no a los receptores muscarínicos o benzodiazepinergic cuales están involucrados también en la epilepsia y otros tipos de convulsiones.
  • Laudanosin ist ein giftiges Benzylisochinolin-Alkaloid, das in kleinen Mengen im Schlafmohn vorkommt und strukturell mit Papaverin verwandt ist (N-Methyl-tetrahydropapaverin). Weiterhin ist es ein potentiell toxisches Abbauprodukt der Muskelrelaxanzien Atracurium und (in geringerem Ausmaß) Cisatracurium.
  • Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium.
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  • Laudanosin ist ein giftiges Benzylisochinolin-Alkaloid, das in kleinen Mengen im Schlafmohn vorkommt und strukturell mit Papaverin verwandt ist (N-Methyl-tetrahydropapaverin). Weiterhin ist es ein potentiell toxisches Abbauprodukt der Muskelrelaxanzien Atracurium und (in geringerem Ausmaß) Cisatracurium. Laudanosin durchdringt die Blut-Hirn-Schranke und wirkt über Interaktionen mit GABA-, Opioid- und nikotinischen Acetylcholinrezeptoren epileptogen, d. h. cerebral erregend. Es kann im Herz-Kreislaufsystem zu Blutdruckabfall (Hypotonie) und verlangsamtem Herzschlag (Bradykardie) führen. In der Praxis spielen die Wirkungen von Laudanosin bei den üblichen Dosierungen der Muskelrelaxanzien in der Regel allerdings keine Rolle. Es erhöht weiterhin den MAC-Wert der verwendeten volatilen Narkotika bei einer Narkose. Laudanosin wird renal ausgeschieden.
  • La laudanosina es un alcaloide benciltetrahidroisoquinolínico del opio. La laudanosina disminuye el umbral de convulsiones, por lo que puede inducir convulsiones si están presentes en concentraciones suficientes de umbral. Fue aislado por primera vez en 1871. LA hidrogenación parcial de la laudanosina produce la papaverina. Se ha encontrado que este alcaloide interactúa con los receptores GABA, receptores opioidesy receptores nicotínicospero no a los receptores muscarínicos o benzodiazepinergic cuales están involucrados también en la epilepsia y otros tipos de convulsiones.
  • Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. Laudanosine also occurs naturally in minute amounts (0.1%) in opium, from which it was first isolated in 1871. Partial dehydrogenation of laudanosine will lead to papaverine, the alkaloid found in the opium poppy plant (Papaver somniferum). Laudanosine is a benzyltetrahydroisoquinoline alkaloid. It has been shown to interact with GABA receptors, glycine receptors, opioid receptors, and nicotinic acetylcholine receptors, but not benzodiazepine or muscarinic receptors which are also involved in epilepsy and other types of seizures.
IUPAC name
  • (1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy- 2-methyl-3,4-dihydro-1H-isoquinoline
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  • N-Methyl-1,2,3,4-tetrahydropapaverine
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