About: Histone acetylation and deacetylation   Goto Sponge  NotDistinct  Permalink

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Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, Acetyl-Coenzyme A) to another. Deacetylation is simply the reverse reaction where an acetyl group is removed from a molecule.

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  • Histone acetylation and deacetylation
  • Acetilação e deacetilação de histona
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  • Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, Acetyl-Coenzyme A) to another. Deacetylation is simply the reverse reaction where an acetyl group is removed from a molecule.
  • Na acetilação e deacetilação de histona, as histonas são acetiladas e deacetiladas em resíduos de lisina na ramificação N-terminal como parte da regulação genética. Tipicamente, estas reações são catalisadas por enzimas com atividade "histona acetiltransferase" (HAT) ou "histona deacetilase" (HDAC ou HD). Diversas formas de HATs e HDs têm sido identificadas. Entre eles, CBP/p300 é provavelmente a mais importante, devido a poder interagir com numerosos reguladores de transcrição.
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