About: Hemagglutinin (influenza)

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Influenza hemagglutinin (HA) or haemagglutinin (British English) is a homotrimeric glycoprotein found on the surface of influenza viruses and is integral to its infectivity. Hemagglutinin is a Class I Fusion Protein, having multifunctional activity as both an attachment factor and membrane fusion protein. Therefore, HA is responsible for binding Influenza virus to sialic acid on the surface of target cells, such as cells in the upper respiratory tract or erythrocytes, causing as a result the internalization of the virus. Secondarily, HA is responsible for the fusion of the viral envelope with the late endosomal membrane once exposed to low pH (5.0-5.5).

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity protein yago:SocialGroup107950920 yago:Unit108189659
rdfs:label	Hämagglutinin (Influenzavirus A) (de) Hemaglutinina (influenza) (es) Hemagglutinin (influenza) (en) Гемагглютинин вируса гриппа (ru)
rdfs:comment	Hämagglutinin (HA) ist ein Glycoprotein des Influenzavirus A. Es ist eines der drei integralen Membranproteine im Virion und auf der Zelloberfläche infizierter Zellen. Hämagglutinine kommen auch in anderen Viren vor. (de) La gripe hemaglutinina (HA) es una glucoproteína homotrimérica que se encuentra en la superficie de los virus de la gripe y es parte integral de su infectología. La hemaglutinina es una proteína de fusión de clase I, con actividad multifuncional tanto como factor de fijación, como proteína de fusión de membranas.Por lo tanto, la HA es responsable de la unión del virus de la gripe al ácido siálico sobre la superficie de las células diana, como las células de las vías respiratorias superiores o los eritrocitos, tras lo cual el virus está interiorizado. En segundo lugar, la HA es responsable de la fusión de la envoltura viral con la membrana endosómica una vez expuesta a pH bajo (5,0-5,5). (es) Influenza hemagglutinin (HA) or haemagglutinin (British English) is a homotrimeric glycoprotein found on the surface of influenza viruses and is integral to its infectivity. Hemagglutinin is a Class I Fusion Protein, having multifunctional activity as both an attachment factor and membrane fusion protein. Therefore, HA is responsible for binding Influenza virus to sialic acid on the surface of target cells, such as cells in the upper respiratory tract or erythrocytes, causing as a result the internalization of the virus. Secondarily, HA is responsible for the fusion of the viral envelope with the late endosomal membrane once exposed to low pH (5.0-5.5). (en) Гемагглютинин вируса гриппа (HA) — гомотримерный гликопротеин, обнаруживаемый на поверхности вируса гриппа и являющийся ключевым для его механизма заражения. Гемагглютинин — белок слияния класса I, помимо функции присоединения к мембране клетки, в дальнейшем также непосредственно осуществляющий слияние мембран. Таким образом, гемагглютинин, с одной стороны, отвечает за присоединение вируса гриппа к молекуле сиаловой кислоты на мембране клетки-мишени — в частности, клеток верхних дыхательных путей или эритроцитов, с последующим эндоцитозом вируса. Далее, оказываясь в среде с низким pH (5.0-5.5), гемагглютинин вызывает слияние оболочки вируса с мембранной эндосомой. (ru)
name	Hemagglutinin (en) Influenza C hemagglutinin stalk (en)
foaf:depiction
dcterms:subject	Influenza A virus Viral structural proteins
Wikipage page ID	501384 (xsd:integer)
Wikipage revision ID	1122136292 (xsd:integer)
Link from a Wikipage to another Wikipage	Endocytosis Endosome Epitope Monomer Antigenic shift Human Vertebrate Viral neuraminidase In vitro Influenza A virus Influenza A virus subtype H5N1 Influenza A virus subtype H5N2 Antibody-dependent cell-mediated cytotoxicity Viral protein Protein fold class Complement system Conserved sequence Influenza A virus British English CR6261 Viral structural proteins Agglutination (biology) H5N1 genetic structure Amino acid Cylinder (geometry) Flu Norway PH Cell membrane Glycoprotein Viral envelope Protease Protein Receptor-mediated endocytosis Receptor (biochemistry) Gull Hemagglutinin Sweden Homotrimer Model organism Disulfide Arbidol C-terminus H5N1 Influenza Antibodies Membrane fusion protein Virus Neuraminidase Neutralizing antibody FI6 (antibody) Lysosome Transmembrane domain Protein precursor N-terminus Sialic acid Respiratory tract Serotype Membrane fusion Fusion peptide Phytohemagglutinin Erythrocytes
Link from a Wikipage to an external page	http://www.fludb.org https://web.archive.org/web/20090327234834/http:/www.callutheran.edu/Academic_Programs/Departments/BioDev/omm/jmol/flu_div/start.html http://www.pdbe.org/emsearch/hemagglutinin*
sameAs	Hemagglutinin (influenza) Hemagglutinin (influenza) Hemagglutinin (influenza)

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