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George Ralph Mines was a pioneering English cardiac electrophysiologist. He made two important contributions to cardiac electrophysiology. First, he proposed that an action potential wave front could propagate in a circle, repeatedly activating the tissue. Second, he discovered the vulnerable period of the heart: the time during the cardiac cycle when a single stimulus can induce ventricular fibrillation. On November 7, 1914, Mines was found unconscious in his laboratory, and died later that day. His death may have been caused by self-experimentation using electrical stimuli.

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  • George Ralph Mines
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  • George Ralph Mines was a pioneering English cardiac electrophysiologist. He made two important contributions to cardiac electrophysiology. First, he proposed that an action potential wave front could propagate in a circle, repeatedly activating the tissue. Second, he discovered the vulnerable period of the heart: the time during the cardiac cycle when a single stimulus can induce ventricular fibrillation. On November 7, 1914, Mines was found unconscious in his laboratory, and died later that day. His death may have been caused by self-experimentation using electrical stimuli.
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  • George Ralph Mines
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  • British electrophysiologist
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  • George
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  • George Ralph Mines was a pioneering English cardiac electrophysiologist. He made two important contributions to cardiac electrophysiology. First, he proposed that an action potential wave front could propagate in a circle, repeatedly activating the tissue. Second, he discovered the vulnerable period of the heart: the time during the cardiac cycle when a single stimulus can induce ventricular fibrillation. On November 7, 1914, Mines was found unconscious in his laboratory, and died later that day. His death may have been caused by self-experimentation using electrical stimuli. A special issue of the Journal of Physiology was published in September 2013 in honor of the 100th anniversary of Mines' most notable work and his death.
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