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About: Gabaculine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ChemicalSubstanceType, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatNeurotoxinsyago:Inhibitor114724436yago:Matter100020827yago:Neurotoxin115036321yago:PhysicalEntity100001930yago:Poison115032376yago:WikicatGABAReuptakeInhibitorsyago:WikicatGABATransaminaseInhibitorschemical compoundyago:Substance100020090yago:Toxin115034074umbel-rc:ChemicalSubstanceType New Facet based on Instances of this Class

Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor. Gabaculine is also known as 3-amino-2,3-dihydrobenzoic acid hydrochloride and 5-amino cyclohexa-1,3 dienyl carboxylic acid. Gabaculine increased GABA levels in the brain and had an effect on convulsivity in mice.