East Branch Chillisquaque Creek is a tributary of Chillisquaque Creek in Columbia County and Montour County in Pennsylvania, United States. It is approximately 6.2 miles (10.0 km) long and flows through Madison Township, Columbia County and Derry Township, Montour County. At its mouth, it combines with Middle Branch Chillisquaque Creek to form Chillisquaque Creek. White Hall Creek is a tributary of East Branch Chillisquaque Creek. The creek's watershed has an area of 9.75 square miles (25.3 km2). It is situated over sandstone and shale. The main land uses in the watershed include forested land and agricultural land, although there are some areas of wetlands and open water as well.