Dose fractionation effects are utilised in the treatment of cancer with radiation therapy. When the total dose of radiation is divided into several, smaller doses over a period of several days, there are fewer toxic effects on healthy cells. This maximizes the effect of radiation on cancer and minimizes the negative side effects. A typical fractionation scheme divides the dose into 30 units delivered every weekday over six weeks. Hypofractionation is a treatment regimen that delivers higher doses of radiation in fewer visits, which tends to lower the effects of accelerated tumor growth that typically occurs during the later stages of radiotherapy. Hyperfractionation is dividing the same total dose into more deliveries, so that treatments are given more than once a day. Hyperfractionated ra
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| - Fraccionamiento de la dosis (es)
- Dose fractionation (en)
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| - Dose fractionation effects are utilised in the treatment of cancer with radiation therapy. When the total dose of radiation is divided into several, smaller doses over a period of several days, there are fewer toxic effects on healthy cells. This maximizes the effect of radiation on cancer and minimizes the negative side effects. A typical fractionation scheme divides the dose into 30 units delivered every weekday over six weeks. Hypofractionation is a treatment regimen that delivers higher doses of radiation in fewer visits, which tends to lower the effects of accelerated tumor growth that typically occurs during the later stages of radiotherapy. Hyperfractionation is dividing the same total dose into more deliveries, so that treatments are given more than once a day. Hyperfractionated ra (en)
- En radioterapia, el fraccionamiento de la dosis es la división de la dosis total de radiación ionizante de un tratamiento, en sesiones o fracciones a lo largo del tiempo, que se determina por múltiples factores como: la intención del tratamiento (paliativa o radical), el , el tipo de enfermedad oncológica y la localización tumoral. El fraccionamiento de la dosis implica las principales variables en un curso de radioterapia como son el número de fracciones, la dosis por fracción, la dosis total administrada y el tiempo total de tratamiento. (es)
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| - Dose fractionation effects are utilised in the treatment of cancer with radiation therapy. When the total dose of radiation is divided into several, smaller doses over a period of several days, there are fewer toxic effects on healthy cells. This maximizes the effect of radiation on cancer and minimizes the negative side effects. A typical fractionation scheme divides the dose into 30 units delivered every weekday over six weeks. Hypofractionation is a treatment regimen that delivers higher doses of radiation in fewer visits, which tends to lower the effects of accelerated tumor growth that typically occurs during the later stages of radiotherapy. Hyperfractionation is dividing the same total dose into more deliveries, so that treatments are given more than once a day. Hyperfractionated radiation therapy is given over the same period of time (days or weeks) as standard radiation therapy. Accelerated fractionation (two deliveries per day and/or deliveries on weekends as well) has also been investigated. (en)
- En radioterapia, el fraccionamiento de la dosis es la división de la dosis total de radiación ionizante de un tratamiento, en sesiones o fracciones a lo largo del tiempo, que se determina por múltiples factores como: la intención del tratamiento (paliativa o radical), el , el tipo de enfermedad oncológica y la localización tumoral. El fraccionamiento de la dosis implica las principales variables en un curso de radioterapia como son el número de fracciones, la dosis por fracción, la dosis total administrada y el tiempo total de tratamiento. El fraccionamiento de la dosis en radioterapia es una forma de optimizar el efecto de la radiación sobre el tumor y los tejidos sanos, junto con la dosis total administrada y el intervalo de tiempo entre sesiones. Permite disminuir los en los tejidos normales, aumentando el efecto antitumoral en los tejidos cancerosos por:
* Reparación de las lesiones radioinducidas entre cada fracción en el tejido normal.
* Mínima reparación en el tejido tumoral entre cada fracción. La dosis de radioterapia se mide en Gray(Gy) o centigray (cGy), que corresponde a la dosis absorbida de radiaciones ionizantes por volumen de tejido (normal o tumoral). (es)
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