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Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20-25 base pairs long with a two-base overhang on the 3' end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).

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  • دايسر
  • Dicer
  • Dicer
  • Dicer
  • Ribonucleasi III
  • Dicer
  • Dicer
  • Dicer
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  • Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20-25 base pairs long with a two-base overhang on the 3' end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).
  • دايسر (بالإنجليزية: Dicer) هو إنزيم يدخل في تشكيل الميكرو حمض ريبي نووي لدى حقيقيات النوى العليا، لديه أربع مجالات بروتينية.
  • Dicer est une enzyme impliquée dans le processus d'ARN interférence. Ses quatre domaines protéiques sont encodés par le gène DICER1. Dans ce processus, elle intervient dans la formation de microARN et de siRNA chez les eucaryotes supérieurs, en coupant respectivement un pre-microARN (pre-miARN) ou un ARNm double brin. La coupure est asymétrique (bouts libres de 2 nucléotides). Les fragments obtenus sont d'environ 20-25 paires de bases. La suite du processus requiert l'intervention du complexe RISC qui contient la protéine argonaute.
  • Le ribonucleasi III sono enzimi della classe delle idrolasi, che catalizzano il taglio endonucleolitico di un 5'-fosfomonoestere. In particolare, la ribonucleasi III nota come dicer è coinvolta nella degradazione di lunghe molecole di RNA a doppio filamento (dsRNAs) e di pre-microRNA (miRNA) in filamenti di 21 nucleotidi (gli siRNA) durante il processo della RNA interference. Il suo nome (che in italiano potrebbe essere tradotto come generatore di dadi), deriva proprio dalla sua capacità di ridurre molecole di dimensione eterogenea in piccoli blocchi di dimensione omogenea. Il nome fu coniato da Emily Bernstein, una ricercatrice del Cold Spring Harbor Laboratory che per prima individuò tale particolarità nell'enzima.Secondo recenti evidenze, dicer fa parte del complesso RISC.
  • Dicer é uma enzima nuclease que cliva moléculas de RNA dupla fita (dsRNA). A atividade enzimática da Dicer é responsável pela formação de miRNAs e de siRNA: dois tipos de pequenas moléculas de RNA envolvidas em mecanismos de RNA de interferência (RNAi).
  • Dicer ist ein RNase-III-ähnliches Enzym. Es enthält zwei RNase-III-Domänen und eine PAZ-Domäne. Der Abstand zwischen diesen beiden Domänen wird durch einen Helixbereich bestimmt, dessen Länge die Länge der entstehenden siRNAs bestimmt. Dicer katalysiert den ersten Schritt der RNA-Interferenz und initiiert die Bildung des RNA-induced silencing complex (RISC), dessen Endonuklease „argonaute“ in der Lage ist, mRNA abzubauen, deren Sequenz komplementär zu der entstandenen siRNA ist.
  • Dicer es una ribonucleasa miembro de la familia de las ARNasa III (EC 3.1.26.3). Es una gran proteína (>200 kD) monomérica presente en el citoplasma celular. Dicer cataliza el primer paso del mecanismo de RNAi: corta ARN doble banda (ARNdb o dsRNA) y pre-microARN (pre-miARN) en fragmentos de ARN de interferencia pequeños llamados ARNip (siRNAs y miRNAs) de 20-25 nucleótidos, con dos bases libres en los extremos 3' hidroxilo y un extremo 5' fosfato. Archivo:SiRNA structure2.jpg Las enzimas Dicer contienen:
  • Dicer — рибонуклеаза из семейства РНКазы III (RNase III), которая разрезает двуцепочечные молекулы РНК и пре-микроРНК (pre-miRNA) с получением коротких двухцепочечных РНК-фрагментов, называемых малыми интерферирующими РНК (siRNA), и микроРНК (miRNA) соответственно. Данные фрагменты имеют длину приблизительно 20-25 нуклеотидов, обычно с оверхенгом в 2-3 нуклеотида на 3' конце.
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