Dayton Union Station was a railroad station serving Dayton, Ohio with daily passenger trains of several railroads. The station was located at 251 W. Sixth Street at the intersection of Ludlow Street, and it opened in 1900, replacing an earlier depot built in the mid-1850s. It was owned by the Dayton Union Railroad Co., which was owned by the Cincinnati, Hamilton and Dayton Railway, the Cleveland, Cincinnati, Chicago and St. Louis Railway, and the Pittsburgh, Cincinnati, Chicago and St. Louis Railroad. Through a series of mergers over the years, it was ultimately owned by the New York Central Railroad, Baltimore & Ohio Railroad, and Pennsylvania Railroad.