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The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms. In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.”

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  • Daf-2
  • Daf-2
  • Daf-2
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  • The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms. In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.”
  • DAF-2是秀麗隱桿線蟲(Caenorhabditis elegans)的一个基因,编码人胰岛素样生长因子1受体(IGF-1R)的同源蛋白。DAF-2是第一个发现的与老化速率有关的代謝途徑基因。DAF-2也与生殖发育的调控,氧化应激的应对,温度耐受,缺氧以及对细菌病原体的抵抗有关。Cynthia Kenyon获得的DAF-2突变体线虫寿命为普通线虫的两倍。
  • El Gen Daf-2 codifica un receptor insulínico en el gusano C. elegans. Las mutaciones en este gen le han mostrado a la investigadora Cynthia Kenyon que los gusanos C. elegans han aumentado su esperanza de vida al doble de lo normal en ellos. Se conoce que este gen es el encargado de regular el desarrollo reproductivo, el envejecimiento, el estrés oxidativo, la tolerancia a la temperatura, la resistencia a la hipoxia y también la resistencia a bacterias patógenas.
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  • The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms. In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.”
  • El Gen Daf-2 codifica un receptor insulínico en el gusano C. elegans. Las mutaciones en este gen le han mostrado a la investigadora Cynthia Kenyon que los gusanos C. elegans han aumentado su esperanza de vida al doble de lo normal en ellos. Se conoce que este gen es el encargado de regular el desarrollo reproductivo, el envejecimiento, el estrés oxidativo, la tolerancia a la temperatura, la resistencia a la hipoxia y también la resistencia a bacterias patógenas. DAF-2 es el único factor de crecimiento insulínico tipo 1 o IGF-1. La señalización de esta proteína se ha conservado de gusanos a humanos.El DAF-2 actúa negativamente en la regulación del factor forkhead de transcripción DAF-16 a través de una cascada de fosforilación. El análisis genético revela que el DAF-16 es necesario para el daf-2, y que influyen en el aumento de la esperanza de vida. Cuando no fosforaliza, el DAF-16 está activo y presente en el núcleo.
  • DAF-2是秀麗隱桿線蟲(Caenorhabditis elegans)的一个基因,编码人胰岛素样生长因子1受体(IGF-1R)的同源蛋白。DAF-2是第一个发现的与老化速率有关的代謝途徑基因。DAF-2也与生殖发育的调控,氧化应激的应对,温度耐受,缺氧以及对细菌病原体的抵抗有关。Cynthia Kenyon获得的DAF-2突变体线虫寿命为普通线虫的两倍。
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