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Cisatracurium (formerly recognized as 51W89, and marketed as Nimbex) is a bisbenzyltetrahydroisoquinolinium that has effect as a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It shows intermediate duration of action. Cisatracurium is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture.

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rdf:type
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  • Cisatracurium
  • Cisatracurium besilate
  • Cisatracurium
  • Cisatracurium besilato
  • Cisatrakurium
  • Cis-atracúrio
  • Цисатракурия безилат
rdfs:comment
  • Le cisatracurium est un curare non-dépolarisant de la famille des benzylisoquinolines commercialisé sous forme de bésilate de cisatracurium (Nimbex ®). Il est utilisé comme myorelaxant en anesthésie générale et chez les patients en réanimation.
  • Cisatracurium entspricht dem cis-cis-Isomer des Racemats Atracurium.Es führt im Gegensatz zu Atracurium nicht zu einer Histaminfreisetzung.Der Abbau erfolgt zu 80–90 % durch Hofmann-Elimination und nur zum geringen Teil durch unspezifische Esterasen im Plasma. Die erreichten Spiegel von Laudanosin sind niedriger als bei Atracurium. Als Arzneistoff wird Cisatracurium vorwiegend als Benzolsulfonsäure-Salz (Besilat) eingesetzt. Der Name wurde von Burroughs Wellcome (jetzt GlaxoSmithKline) entworfen. Der Präparatenamen Nimbex steht für „exzellenter neuromuskulärer Blocker“ (siehe Muskelrelaxans) (engl. excellent Neuromuscular blocker).
  • Cisatracurium besilato (nella fase sperimentale conosciuto anche con la sigla 51W89) è un rilassante muscolare, più precisamente un bloccante neuromuscolare (ovvero un agente che induce paralisi muscolare), non depolarizzante, ad attività periferica e di tipo competitivo.Si tratta di un agente bisbenziltetraidroisoquinolinium, caratterizzato da una durata d'azione intermedia. Cisatracurium è uno dei dieci isomeri del bloccante neuromuscolare atracurium besilato. Inoltre questo composto rappresenta circa il 15% della miscela racema di atracurium.
  • Cisatracurium (formerly recognized as 51W89, and marketed as Nimbex) is a bisbenzyltetrahydroisoquinolinium that has effect as a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It shows intermediate duration of action. Cisatracurium is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture.
  • Cisatrakurium, benzenosulfonian cisatracurium (ATC M 03 AC) – organiczny związek chemiczny; lek należący do grupy niedepolaryzujących środków zwiotczających o średnio długim czasie działania, stosowanych w anestezjologii w celu zwiotczenia mięśni szkieletowych w przebiegu znieczulenia ogólnego.
  • Цисатракурия безилат — недеполяризующий миорелаксант средней продолжительности действия, применяемый для расслабления скелетных мышц во время интубации трахеи, ИВЛ, хирургических вмешательств.
  • Cis-atracúrio (também chamado de besilato de cisatracúrio, nome comercial Nimbex) é um fármaco bloqueador neuromuscular de administração endovenosa (ou relaxante muscular esquelético). Comparado com outros agentes bloqueadores neuromusculares tem um início e duração de acção intermédios. É um de dez isómeros do Atracúrio. A fórmula molecular do cis-atracúrio purificado é C53H72N2O2, tendo um peso molecular de 929,2. A fórmula do sal, besilato de cis-atracúrio é C65H82N2O18S2, com um peso molecular de 1243,50.
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