Mrs Charlotte Melmoth (c. 1749 – 1823) was an 18th-century English actress, the estranged spouse of British actor/writer Samuel Jackson Pratt ("Courtney Melmoth"), and known as "The Grande Dame of Tragedy on the Early American Stage". After a moderately successful stage career in Great Britain and Ireland, she emigrated to the United States of America in 1793 and became one of the best-known actresses of the late 18th/early 19th century.