Charles Thomas Caskey (September 12, 1938 – January 13, 2022), also known as C. Thomas Caskey, was an American internist who has been a medical Geneticist and biomedical researcher and entrepreneur. He was a Professor of Molecular and Human Genetics at Baylor College of Medicine, and served as editor of the Annual Review of Medicine from 2001-2019. He was a member of the editorial boards of the Proceedings of the National Academy of Science, Science, the Encyclopedia of Molecular Medicine and numerous other medical and scientific journals.