Charles Edward "Buzz" Wetzel (August 25, 1894 – March 7, 1941) was a pitcher in Major League Baseball who played briefly for the Philadelphia Athletics during the 1927 season. Listed at 6 ft 1 in (1.85 m), 162 lb., Wetzel batted and threw right-handed. He was born in Jay, Oklahoma. Following his majors career, Wetzel pitched and managed in the minor leagues. Wetzel died in Globe, Arizona, at the age of 46.