About: Bacterial effector protein

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Bacterial effectors are proteins secreted by pathogenic bacteria into the cells of their host, usually using a type 3 secretion system (TTSS/T3SS), a type 4 secretion system (TFSS/T4SS) or a Type VI secretion system (T6SS). Some bacteria inject only a few effectors into their host’s cells while others may inject dozens or even hundreds. Effector proteins may have many different activities, but usually help the pathogen to invade host tissue, suppress its immune system, or otherwise help the pathogen to survive. Effector proteins are usually critical for virulence. For instance, in the causative agent of plague (Yersinia pestis), the loss of the T3SS is sufficient to render the bacteria completely avirulent, even when they are directly introduced into the bloodstream. Gram negative microbes

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rdf:type	yago:WikicatBacterialProteins yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:label	Bacterial effector protein (en)
rdfs:comment	Bacterial effectors are proteins secreted by pathogenic bacteria into the cells of their host, usually using a type 3 secretion system (TTSS/T3SS), a type 4 secretion system (TFSS/T4SS) or a Type VI secretion system (T6SS). Some bacteria inject only a few effectors into their host’s cells while others may inject dozens or even hundreds. Effector proteins may have many different activities, but usually help the pathogen to invade host tissue, suppress its immune system, or otherwise help the pathogen to survive. Effector proteins are usually critical for virulence. For instance, in the causative agent of plague (Yersinia pestis), the loss of the T3SS is sufficient to render the bacteria completely avirulent, even when they are directly introduced into the bloodstream. Gram negative microbes (en)
dcterms:subject	Bacterial proteins
Wikipage page ID	40822244 (xsd:integer)
Wikipage revision ID	1087169278 (xsd:integer)
Link from a Wikipage to another Wikipage	Endocytosis MAPK/ERK pathway Membrane vesicle trafficking Pathogenic Escherichia coli Verotoxin-producing Escherichia coli Homeostasis Phagocytes Inflammation dbr:Interleukin_8 Pathogenic bacteria Protein phosphorylation Pseudomonas syringae Innate immunity Escherichia coli O157:H7 Phagocytosis Pseudomonas aeruginosa Salmonella enterica Secretory pathway GDP Apoptosis Caco-2 Microfold cell Host-pathogen interface Bacterial proteins Cell (biology) GTPase Acetyl group Actinopterygii Cytokines Escherichia coli Golgi apparatus Yersinia pestis Legionella pneumophila Protein Rab (G-protein) Bacterial outer membrane vesicles Acetyltransferase Chlamydia (genus) Transcytosis Virulence Salmonella Plague (disease) Integrin Interferons Interleukins Antibodies Lysosome Secretion Yersinia Yersinia enterocolitica Type VI secretion system Yersinia pseudotuberculosis MDM2 Shigella SOBER1 Gram negative E. coli O157:H7 Complement proteins NF-kB Type 3 secretion system
Link from a Wikipage to an external page	http://biocomputer.bio.cuhk.edu.hk/T3DB/ http://systbio.cau.edu.cn/bean/ https://effectors.csb.univie.ac.at/ https://web.archive.org/web/20141122124331/http:/effectors.bic.nus.edu.sg/T3SEdb/index.php https://web.archive.org/web/20160304025350/https:/www.staff.ncl.ac.uk/p.dean/Bacterial_effectors_and_their_/body_bacterial_effectors_and_their_.html
sameAs	Bacterial effector protein Bacterial effector protein Bacterial effector protein Bacterial effector protein
dbp:wikiPageUsesTemplate	dbt:Fact dbt:Reflist
has abstract	Bacterial effectors are proteins secreted by pathogenic bacteria into the cells of their host, usually using a type 3 secretion system (TTSS/T3SS), a type 4 secretion system (TFSS/T4SS) or a Type VI secretion system (T6SS). Some bacteria inject only a few effectors into their host’s cells while others may inject dozens or even hundreds. Effector proteins may have many different activities, but usually help the pathogen to invade host tissue, suppress its immune system, or otherwise help the pathogen to survive. Effector proteins are usually critical for virulence. For instance, in the causative agent of plague (Yersinia pestis), the loss of the T3SS is sufficient to render the bacteria completely avirulent, even when they are directly introduced into the bloodstream. Gram negative microbes are also suspected to deploy bacterial outer membrane vesicles to translocate effector proteins and virulence factors via a membrane vesicle trafficking secretory pathway, in order to modify their environment or attack/invade target cells, for example, at the host-pathogen interface. (en)
gold:hypernym	Proteins
prov:wasDerivedFrom	wikipedia-en:Bacterial_effector_protein?oldid=1087169278&ns=0
page length (characters) of wiki page	30223 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Bacterial_effector_protein
is Link from a Wikipage to another Wikipage of	Bacterial Effector proteins Brian Staskawicz

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