About: Azoospermia factor

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Azoospermia factor (AZF) is one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa (sometimes AZF1), AZFb and AZFc (together referred to as AZF2). AZF microdeletions are one of the major causes of male infertility for azoospermia (complete absence of sperm in the ejaculate) and severe oligozoospermia (less than 5 million spermatozoa in the ejaculate) males. AZF is the term used by the HUGO Gene Nomenclature Committee.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:WikicatChromosomes yago:Body109224911 yago:Chromosome105442131 yago:NaturalObject100019128 yago:Object100002684 yago:PhysicalEntity100001930 protein yago:Whole100003553 umbel-rc:ProteinMolecule
rdfs:label	Azoospermia factor (en)
rdfs:comment	Azoospermia factor (AZF) is one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa (sometimes AZF1), AZFb and AZFc (together referred to as AZF2). AZF microdeletions are one of the major causes of male infertility for azoospermia (complete absence of sperm in the ejaculate) and severe oligozoospermia (less than 5 million spermatozoa in the ejaculate) males. AZF is the term used by the HUGO Gene Nomenclature Committee. (en)
foaf:name	azoospermia factor 1 (en)
name	azoospermia factor 1 (en)
dcterms:subject	Chromosomes
Wikipage page ID	6830589 (xsd:integer)
Wikipage revision ID	1079513150 (xsd:integer)
Link from a Wikipage to another Wikipage	Meiosis Chromosomes Male infertility Anatomical terms of location Centromere Chromosome Testes Y chromosome Azoospermia Sperm Infertility Euchromatin Spermatogenesis USP9Y dbr:Genetic_degeneracy
Link from a Wikipage to an external page	https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi%3Fbook=gene&part=yci
sameAs	Azoospermia factor Azoospermia factor Azoospermia factor Azoospermia factor
dbp:wikiPageUsesTemplate	dbt:Redirect dbt:Reflist dbt:Short_description dbt:Vanchor dbt:Infobox_protein
AltSymbols	AZF (en)
symbol	AZF1 (en)
has abstract	Azoospermia factor (AZF) is one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa (sometimes AZF1), AZFb and AZFc (together referred to as AZF2). AZF microdeletions are one of the major causes of male infertility for azoospermia (complete absence of sperm in the ejaculate) and severe oligozoospermia (less than 5 million spermatozoa in the ejaculate) males. AZF is the term used by the HUGO Gene Nomenclature Committee. Of the 15% of couples who are affected by infertility, 50% of those cases are due to the male partner. 15-30% of male factor infertility cases can be correlated with genetic abnormalities. One of the most commonly identified genetic abnormalities in male factor infertility are microdeletions on the long arm of the Y chromosome (Yq), specifically at a region known as the azoospermic factor (AZF) region. In certain circumstances, men with AZF mutations can turn to assisted reproductive technologies (ART), such as intracytoplasmic sperm injection (ICSI), to help them overcome their suboptimal sperm quality. However, it may be more important for clinicians to screen for Yq microdeletions, due to a growing body of evidence that AZF microdeletions have the capability to be vertically transmitted to male offspring. Minor et al. demonstrated that an AZFc mutation was vertically transmitted over three generations via fathers receiving reproductive assistance through ICSI. (en)
Arm	q (en)
band	11 (xsd:integer)
Chromosome	Y (en)
EntrezGene	560 (xsd:integer)
HGNCid	908 (xsd:integer)
arm	q
band	11
chromosome	Y
EntrezGene	560
HGNCid	908
prov:wasDerivedFrom	wikipedia-en:Azoospermia_factor?oldid=1079513150&ns=0
page length (characters) of wiki page	10049 (xsd:nonNegativeInteger)
Symbol	AZF AZF1
foaf:isPrimaryTopicOf	wikipedia-en:Azoospermia_factor
is Link from a Wikipage to another Wikipage of	AZF Azoospermia Factor DAZ2 DAZ3 Y linkage Sertoli cell-only syndrome Azoospermia factor locus Gr/gr Gr/gr deletion AZF1 AZF2 AZF region AZFc
is Wikipage redirect of	Azoospermia Factor Azoospermia factor locus Gr/gr Gr/gr deletion AZF1 AZF2 AZF region AZFc
is foaf:primaryTopic of	wikipedia-en:Azoospermia_factor

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