About: Abecarnil

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: Abecarnil Goto Sponge NotDistinct Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)
QRcode icon

http://dbpedia.org/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FAbecarnil

Abecarnil (ZK-112,119) is an anxiolytic drug from the β-Carboline family. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. It is a partial agonist acting selectively at the benzodiazepine site of the GABAA receptor. Abecarnil is a relatively subtype-selective drug which produces primarily anxiolytic effects, with comparatively less sedative or muscle relaxant properties, and does not significantly potentiate the effects of alcohol.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatCarboxylateEsters yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Element114840755 yago:Ester114850483 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 drug yago:Substance100019613 yago:WikicatEthers yago:WikicatPhenolEthers umbel-rc:DrugProduct
rdfs:label	Abecarnil (en)
rdfs:comment	Abecarnil (ZK-112,119) is an anxiolytic drug from the β-Carboline family. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. It is a partial agonist acting selectively at the benzodiazepine site of the GABAA receptor. Abecarnil is a relatively subtype-selective drug which produces primarily anxiolytic effects, with comparatively less sedative or muscle relaxant properties, and does not significantly potentiate the effects of alcohol. (en)
foaf:depiction
dcterms:subject	Carboxylate esters GABAA receptor positive allosteric modulators Beta-Carbolines Anxiolytics Indole ethers at the benzene ring Isopropyl esters
Wikipage page ID	13385614 (xsd:integer)
Wikipage revision ID	1123673319 (xsd:integer)
Link from a Wikipage to another Wikipage	Partial agonist Benzodiazepine dbr:Beta-Carboline Carboxylate esters GABAA receptor positive allosteric modulators Chemical structure Full agonist Anxiolytic Substance dependence Muscle relaxant Beta-Carbolines Drug Drug tolerance GABAA receptor Anxiolytics Indole ethers at the benzene ring Nonbenzodiazepine Isopropyl esters Alcoholic beverage Binding selectivity Sedative
sameAs	Abecarnil Abecarnil Abecarnil Abecarnil Abecarnil Abecarnil
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:GABAAR_PAMs dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Anxiolytics
thumbnail	wiki-commons:Special:FilePath/Abecarnil-2D-by-AHRLS-2012.png?width=300
ATC prefix	none (en)
c	24 (xsd:integer)
CAS number	111841 (xsd:integer)
ChEMBL	454095 (xsd:integer)
ChemSpiderID	59323 (xsd:integer)
elimination half-life	25200.0 (second)
H	24 (xsd:integer)
IUPAC name	propan-2-yl 4--6- -9H-pyrido[5,4-b]indole-3-carboxylate (en)
KEGG	D02594 (en)
n	2 (xsd:integer)
O	4 (xsd:integer)
PubChem	65914 (xsd:integer)
SMILES	COCc3cncc4[nH]c2ccccc2c34 (en)
StdInChI	1 (xsd:integer)
StdInChIKey	RLFKILXOLJVUNF-UHFFFAOYSA-N (en)
UNII	IZM1PNJ3JL (en)
Verifiedfields	changes (en)
verifiedrevid	477237117 (xsd:integer)
has abstract	Abecarnil (ZK-112,119) is an anxiolytic drug from the β-Carboline family. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. It is a partial agonist acting selectively at the benzodiazepine site of the GABAA receptor. Abecarnil was originally developed as an anti-anxiety drug, but has not as yet been commercially developed for use in humans, instead so far mainly being used for research into the development of other new sedative and anxiolytic drugs. Investigations are continuing into its actions and it looks likely to be developed for use both in the treatment of anxiety, and as a less addictive substitute drug for the treatment of benzodiazepine and alcohol addiction. Abecarnil may also have fewer problems of tolerance and withdrawal problems compared to nonselective full agonist benzodiazepine acting drugs. Abecarnil is a relatively subtype-selective drug which produces primarily anxiolytic effects, with comparatively less sedative or muscle relaxant properties, and does not significantly potentiate the effects of alcohol. The abuse potential of abecarnil is thought to be less than that of benzodiazepines, with only mild withdrawal symptoms noted after abrupt discontinuation of treatment. (en)
gold:hypernym	Drug
prov:wasDerivedFrom	wikipedia-en:Abecarnil?oldid=1123673319&ns=0
page length (characters) of wiki page	7080 (xsd:nonNegativeInteger)
CAS number	111841-85-1
ChEMBL	454095
FDA UNII code	IZM1PNJ3JL
KEGG	D02594
PubChem	65914
foaf:isPrimaryTopicOf	wikipedia-en:Abecarnil

Faceted Search & Find service v1.17_git139 as of Feb 29 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (62 GB total memory, 54 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software