The 2012 Melbourne Vixens season saw Melbourne Vixens compete in the 2012 ANZ Championship. With a team captained by Bianca Chatfield and featuring Madison Browne, Julie Corletto and Geva Mentor, Vixens finished the season as minor premiers. In the major semi-final they defeated Northern Mystics 56–50. This was the first ever netball match held at Rod Laver Arena. However they lost the grand final 41–38 to Waikato Bay of Plenty Magic and finished the season as runners-up. After five years as head coach of Vixens, Julie Hoornweg announced her retirement at the end of the 2012 season.