The 1949 Dutch motorcycle Grand Prix was the third race of the 1949 Motorcycle Grand Prix season. It took place on the weekend of 9 July 1949 at the Assen circuit. Italian rider Nello Pagani won the 500 cc race riding a Gilera from Leslie Graham and Arciso Artesiani. Pagani also won the 125 cc race on his smaller Gilera which saw him wrap up the first 125 cc World Championship having won the first two 125 cc races with only one race remaining.