The 2016 North Dakota State Bison football team represented North Dakota State University in the 2016 NCAA Division I FCS football season. They were led by third-year head coach Chris Klieman. The team played their 24th season in the Fargodome, entering the season as the five-time defending national champions and five-time Missouri Valley Football Conference Champions. The Bison have been members of the Missouri Valley Football Conference since the 2008 season.