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He was responsible for the health and safety of the thousands of personnel involved in the Manhattan Project. He was present at the Trinity nuclear test in Alamogordo, New Mexico where he was responsible for the safety aspects of the detonation of the world's first nuclear weapon. He led a survey team from the Manhattan Project to assess the effects of the atomic bombings of Hiroshima and Nagasaki. In 1946 he was Chief of the Radiological Safety Section of the Joint Task Force for Operation Crossroads, the nuclear test at Bikini Atoll. In 1947 Warren became the first dean of the School of Medicine at the University of California, Los Angeles (UCLA). Under his leadership, the new school grew from nothing to a major medical school. Warren became Vice Chancellor, Health Services in 1962. From 1963 to 1965 he served as special assistant to President John F. Kennedy and later Lyndon B. Johnson on mental retardation. Returning to UCLA in 1965, he became professor emeritus, a position he held until his death in 1981. 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