@prefix rdf: . @prefix dbpedia: . @prefix ns2: . dbpedia:Ramipril rdf:type ns2:ACEInhibitors , ns2:Prodrugs . @prefix owl: . dbpedia:Ramipril owl:sameAs . @prefix foaf: . @prefix ns5: . dbpedia:Ramipril foaf:page ns5:Ramipril . @prefix dbpprop: . dbpedia:Ramipril dbpprop:reference , . @prefix rdfs: . dbpedia:Ramipril rdfs:label "Ramipril"@hu , "Ramipril"@it , "Ramipryl"@pl , "Ramipril"@en , "Ramipril"@de ; dbpprop:abstract "Ramipril (marketed by Sanofi-Aventis as Tritace and by King Pharmaceuticals as Altace) is an angiotensin-converting enzyme (ACE) inhibitor, used to treat hypertension and congestive heart failure. ACE inhibitors lower the production of angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood more easily, and increasing blood flow due to more blood being pumped into and through larger passageways. Ramipril is a prodrug and is converted to the active metabolite ramiprilat by liver esterase enzymes. Ramiprilat is mostly excreted by the kidneys. The half-life of ramiprilat is variable (3-16 hours), and is prolonged by heart and liver failure, as well as kidney failure. It is marketed by King Pharmaceuticals under the brand name Altace. The compound was protected by the {{US patent|5,061,722 (was scheduled to expire on 29 Oct, 2008) assigned to Aventis. On September 11, 2007 in an appeal by Lupin Pharmaceuticals the United States Court of Appeals for the Federal Circuit reversed a district court trial verdict, finding that Aventis's patent on Altace was invalid for obviousness - opening the gate of this medicine to generic manufacturers. Ramipril is marketed in India under the brand names of Cardace, Zigpril and Zorem."@en , "Ramipril ist ein Arzneistoff der Gruppe der ACE-Hemmer, der zur Behandlung der arteriellen Hypertonie (Bluthochdruck) und der Herzinsuffizienz und zur Vorbeugung des Herzinfarktes eingesetzt wird. Ramipril selbst ist ein inaktives Prodrug. Sein Wirkprinzip beruht nach Aktivierung zum Ramiprilat auf der Hemmung des Angiotensin Converting Enzyme (ACE). In Deutschland ist Ramipril als Delix und Vesdil sowie in Form zahlreicher Generika auf dem Markt."@de , "A ramipril egy angiotenzin-konvert\u00E1l\u00F3 enzim (ACE) g\u00E1tl\u00F3 gy\u00F3gyszer, melyet magas v\u00E9rnyom\u00E1s betegs\u00E9g \u00E9s kr\u00F3nikus sz\u00EDvel\u00E9gtelens\u00E9g kezel\u00E9s\u00E9re adnak. Az ACE g\u00E1tl\u00F3k cs\u00F6kkentik at angiotensin II k\u00E9pz\u0151d\u00E9s\u00E9t \u00E9s ez\u00E1ltal ellaz\u00EDtj\u00E1k az art\u00E9ri\u00E1s simaizmokat \u00E9s t\u00E1g\u00EDtj\u00E1k az art\u00E9ri\u00E1kat \u00EDgy a sz\u00EDv k\u00F6nnyebben tudja a v\u00E9rt pump\u00E1lni \u00E9s a v\u00E9rell\u00E1t\u00E1s javul. A ramipril prodrug mivel a m\u00E1jban alakul akt\u00EDv metabolitt\u00E1 (ramiprilat) \u00E9szter\u00E1z enzimek seg\u00EDts\u00E9g\u00E9vel. A ramiprilat f\u0151k\u00E9nt a ves\u00E9ben v\u00E1laszt\u00F3dik ki, biol\u00F3giai felez\u00E9si ideje 3-16 \u00F3ra k\u00F6z\u00F6tt v\u00E1ltozik."@hu , "Il Ramipril \u00E8 un principio attivo di indicazione specifica contro l\u2019ipertensione."@it , "Ramipryl \u2013 organiczny zwi\u0105zek chemiczny, lek z grupy inhibitor\u00F3w konwertazy angiotensyny stosowany g\u0142\u00F3wnie w terapii nadci\u015Bnienia t\u0119tniczego. Jest prolekiem, jego aktywn\u0105 form\u0105 jest ramiprylat (posiada 6-krotnie silniejsze dzia\u0142anie)."@pl ; rdfs:comment "Ramipryl \u2013 organiczny zwi\u0105zek chemiczny, lek z grupy inhibitor\u00F3w konwertazy angiotensyny stosowany g\u0142\u00F3wnie w terapii nadci\u015Bnienia t\u0119tniczego. Jest prolekiem, jego aktywn\u0105 form\u0105 jest ramiprylat (posiada 6-krotnie silniejsze dzia\u0142anie)."@pl , "A ramipril egy angiotenzin-konvert\u00E1l\u00F3 enzim (ACE) g\u00E1tl\u00F3 gy\u00F3gyszer, melyet magas v\u00E9rnyom\u00E1s betegs\u00E9g \u00E9s kr\u00F3nikus sz\u00EDvel\u00E9gtelens\u00E9g kezel\u00E9s\u00E9re adnak. Az ACE g\u00E1tl\u00F3k cs\u00F6kkentik at angiotensin II k\u00E9pz\u0151d\u00E9s\u00E9t \u00E9s ez\u00E1ltal ellaz\u00EDtj\u00E1k az art\u00E9ri\u00E1s simaizmokat \u00E9s t\u00E1g\u00EDtj\u00E1k az art\u00E9ri\u00E1kat \u00EDgy a sz\u00EDv k\u00F6nnyebben tudja a v\u00E9rt pump\u00E1lni \u00E9s a v\u00E9rell\u00E1t\u00E1s javul. A ramipril prodrug mivel a m\u00E1jban alakul akt\u00EDv metabolitt\u00E1 (ramiprilat) \u00E9szter\u00E1z enzimek seg\u00EDts\u00E9g\u00E9vel."@hu , "Ramipril (marketed by Sanofi-Aventis as Tritace and by King Pharmaceuticals as Altace) is an angiotensin-converting enzyme (ACE) inhibitor, used to treat hypertension and congestive heart failure. ACE inhibitors lower the production of angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood more easily, and increasing blood flow due to more blood being pumped into and through larger passageways."@en , "Il Ramipril \u00E8 un principio attivo di indicazione specifica contro l\u2019ipertensione."@it , "Ramipril ist ein Arzneistoff der Gruppe der ACE-Hemmer, der zur Behandlung der arteriellen Hypertonie (Bluthochdruck) und der Herzinsuffizienz und zur Vorbeugung des Herzinfarktes eingesetzt wird. Ramipril selbst ist ein inaktives Prodrug. Sein Wirkprinzip beruht nach Aktivierung zum Ramiprilat auf der Hemmung des Angiotensin Converting Enzyme (ACE). In Deutschland ist Ramipril als Delix und Vesdil sowie in Form zahlreicher Generika auf dem Markt."@de . @prefix skos: . @prefix ns9: . dbpedia:Ramipril skos:subject ns9:Prodrugs , ns9:ACE_inhibitors . @prefix ns10: . dbpedia:Ramipril dbpprop:hasPhotoCollection ns10:Ramipril . dbpedia:Delix dbpprop:redirect dbpedia:Ramipril . dbpedia:Altace dbpprop:redirect dbpedia:Ramipril . @prefix ns11: . ns11:DB00178 owl:sameAs dbpedia:Ramipril . dbpedia:Ramace dbpprop:redirect dbpedia:Ramipril . dbpedia:Tritace dbpprop:redirect dbpedia:Ramipril . @prefix yago: . yago:Ramipril owl:sameAs dbpedia:Ramipril .