@prefix rdf: . @prefix dbpedia: . @prefix ns2: . dbpedia:Midazolam rdf:type ns2:Benzodiazepines , ns2:Imidazoles , ns2:MuscleRelaxants . @prefix owl: . dbpedia:Midazolam rdf:type owl:Thing , ns2:Anticonvulsants , ns2:Hypnotics , ns2:Sedatives . @prefix dbpedia-owl: . dbpedia:Midazolam rdf:type dbpedia-owl:Drug , ns2:Anxiolytics ; owl:sameAs . @prefix foaf: . @prefix ns6: . dbpedia:Midazolam foaf:page ns6:Midazolam . @prefix ns7: . dbpedia:Midazolam ns7:atcPrefix "N05" ; ns7:atcSuffix "CD08" ; ns7:casNumber "59467-70-8" ; dbpedia-owl:drugbank "APRD00680" ; ns7:drugbank "APRD00680" ; ns7:iupacName "8-chloro- 6-(2-fluorophenyl)- 1-methyl- 4H-imidazo[1,5-a] [1,4]benzodiazepine" ; dbpedia-owl:pubchem "4192" . @prefix dbpprop: . dbpedia:Midazolam dbpprop:reference , , . @prefix rdfs: . dbpedia:Midazolam rdfs:label "Midazolam"@nl , "Midazolam"@no , "Midazolam"@pl , "Midazolam"@pt , "Midazolam"@en , "Midazolam"@ro , "Markus Weissenberger"@es , "\u30DF\u30C0\u30BE\u30E9\u30E0"@ja , "Midatsolaami"@fi , "Midazolam"@es , "Midazolam"@de , "Midazolam"@sv , "Midazolam"@fr , "\u041C\u0438\u0434\u0430\u0437\u043E\u043B\u0430\u043C"@ru , "Midazolam"@hu , "Midazolam"@it ; dbpedia-owl:thumbnail ; dbpedia-owl:atcPrefix "N05" ; dbpedia-owl:atcSuffix "CD08" ; dbpedia-owl:casNumber "59467-70-8" ; dbpedia-owl:iupacName "8-chloro- 6-(2-fluorophenyl)- 1-methyl- 4H-imidazo[1,5-a] [1,4]benzodiazepine" ; ns7:pubchem "4192" ; dbpprop:abstract "F\u00E1jl:Midazolam. svg A midazol\u00E1m szerkezeti k\u00E9plete A midazol\u00E1m (Dormicum) egy ultra r\u00F6vid hat\u00E1s\u00FA benzodiazepin sz\u00E1rmaz\u00E9k. Er\u0151s anxiol\u00EDtikus, amn\u00E9zia-kiv\u00E1lt\u00F3, hipnotikus, antikonvulz\u00EDv, v\u00E1zizomrelax\u00E1ns \u00E9s nyugtat\u00F3 tulajdons\u00E1gai vannak. A midazolam molekul\u00E1ja k\u00FCl\u00F6nleges a benzodiazepinek k\u00F6r\u00E9ben, mivel v\u00EDzben oldhat\u00F3 \u00E9s nem zs\u00EDrban old\u00F3d\u00F3, mint a legt\u00F6bb benzodiazepin. Ultra r\u00F6vid hat\u00E1s\u00FA benzodiazepin, az elimin\u00E1ci\u00F3s felez\u00E9si ideje k\u00F6r\u00FClbel\u00FCl 2 \u00F3ra. Egyes orsz\u00E1gokban alkalmazz\u00E1k az \u00E1lmatlans\u00E1g r\u00F6vid t\u00E1v\u00FA kezel\u00E9s\u00E9re, \u00E9s a m\u0171t\u00E9t el\u0151tti premedik\u00E1ci\u00F3 sor\u00E1n. Nagyon hasznos gy\u00F3gyszer kisebb seb\u00E9szeti m\u0171t\u00E9tek, mint p\u00E9ld\u00E1ul a fogh\u00FAz\u00E1s sor\u00E1n. A midazolamot el\u0151sz\u00F6r 1976-ban szintetiz\u00E1lta Fryer \u00E9s Walser. Dormicum Betegt\u00E1j\u00E9koztat\u00F3"@hu , "Le midazolam est une mol\u00E9cule de la famille des benzodiaz\u00E9pines commercialis\u00E9e sous le nom d'Hypnovel \u00AE. Ses puissantes propri\u00E9t\u00E9s anxiolytiques, amn\u00E9siantes, hypnotiques, anticonvulsantes, s\u00E9datives et myorelaxantes, associ\u00E9es \u00E0 un d\u00E9lai et une dur\u00E9e d'action courts, en font un adjuvant particuli\u00E8rement utile en anesth\u00E9sie et en r\u00E9animation. Le midazolam est par ailleurs indiqu\u00E9, et recommand\u00E9 comme mol\u00E9cule de r\u00E9f\u00E9rence dans la s\u00E9dation des patients pour d\u00E9tresse en phase terminale par la soci\u00E9t\u00E9 fran\u00E7aise d'accompagnement et de soins palliatifs. Cette utilisation est r\u00E9serv\u00E9e aux situations aigu\u00EBs ou r\u00E9fractaires v\u00E9cues par le patient comme insupportables. Le midazolam a \u00E9t\u00E9 synth\u00E9tis\u00E9 en 1976 et mis sur le march\u00E9 en France en 1986. Il n'est disponible en France que sous forme injectable, tandis qu'on le trouve \u00E9galement sous forme orale aux \u00C9tats-Unis."@fr , "Midazolam, C18H13ClFN3, \u00E4r ett \u00E5ngestd\u00E4mpande och lugnande preparat som tillh\u00F6r gruppen bensodiazepiner, patenterat 1976. \u00C4mnet \u00E4r narkotikaklassat. Varunamn i Sverige \u00E4r bland annat Dormicum och Midazolam Alpharma. L\u00E4kemedlet finns b\u00E5de som oral suspention eller som injektionsform. Midazolam anv\u00E4nds vid oro, \u00E5ngest och sp\u00E4nning d\u00E5 snabb effekt \u00F6nskas, till exempel i samband med operationer eller obehagliga unders\u00F6kningar. Medlet p\u00E5verkar fr\u00E4mst det centrala nervsystemet och verkar sp\u00E4nningsl\u00F6sande, muskelavslappande och \u00E5ngestd\u00E4mpande. Risk f\u00F6r tillv\u00E4njning f\u00F6religger."@sv , "\u041C\u0438\u0434\u0430\u0437\u043E\u043B\u0430\u043C (Midazolam) 8-\u0425\u043B\u043E\u0440-6-(2-\u0444\u0442\u043E\u0440\u0444\u0435\u043D\u0438\u043B)-1-\u043C\u0435\u0442\u0438\u043B-4H-\u0438\u043C\u0438\u0434\u0430\u0437\u043E/1,5-a//1,4/\u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D (\u0432 \u0432\u0438\u0434\u0435 \u0433\u0438\u0434\u0440\u043E\u0445\u043B\u043E\u0440\u0438\u0434\u0430 \u0438\u043B\u0438 \u043C\u0430\u043B\u0435\u0430\u0442\u0430) \u0421\u0438\u043D\u043E\u043D\u0438\u043C\u044B: \u0424\u043B\u043E\u0440\u043C\u0438\u0434\u0430\u043B, Dormicum, Dormonid, Flormidal, Versed."@ru , "Midazolam, (merknaam Dormicum\u00AE van Roche en in de VS Versed\u00AEen Hypnovel\u00AE) hoort bij de benzodiazepines. Het heeft sterke anxiolytische, amnestische, hypnotische, anticonvulsieve, spierrelaxerende en sedatieve eigenschappen. Het is een snelwerkende benzodiazepine, de groep medicijnen waar Xanax\u00AE en Valium\u00AE ook toe behoren. Het is een van de weinige wateroplosbare benzodiazepines, en daarom erg geschikt voor injectie. Midazolam is voor het eerst gesynthetiseerd in 1976 door Fryer en Walser."@nl , "Midazolam (Handelsname u. a. Dormicum) ist ein Arzneistoff aus der Gruppe der Benzodiazepine. Es ist verschreibungspflichtig und liegt in Darreichungsformen zur parenteralen und oralen Verabreichung vor. Es kann schon nach kurzer Anwendung zu einer psychischen Abh\u00E4ngigkeit kommen."@de , "\u30DF\u30C0\u30BE\u30E9\u30E0 (midazolam) \u3068\u306F\u30D9\u30F3\u30BE\u30B8\u30A2\u30BC\u30D4\u30F3(BZP)\u7CFB\u306E\u9EBB\u9154\u5C0E\u5165\u85AC\u30FB\u93AE\u9759\u85AC\u3002\u65E5\u672C\u3067\u306E\u5546\u54C1\u540D\u306F\u30C9\u30EB\u30DF\u30AB\u30E0\uFF08\u30A2\u30B9\u30C6\u30E9\u30B9\u88FD\u85AC\u88FD\u9020\u8CA9\u58F2\uFF09\u3002\uFF08\u5F8C\u767A\u54C1\u3042\u308A\uFF09"@ja , "Midazolam, pronounced /m\u026A\u02C8d\u00E6z\u0259l\u00E6m/ (and marketed in English-speaking countries under brand names Dormicum, Hypnovel, Midacum and Versed) is an ultra short-acting benzodiazepine derivative. It has potent anxiolytic, amnestic, hypnotic, anticonvulsant, skeletal muscle relaxant, and sedative properties. Midazolam is water-soluble and fat-soluble in physiologic pH. Freely soluble in alcohol and acetone. It is considered an ultra short-acting benzodiazepine, with an elimination half-life of about 2 hours. It is used in some countries for the short term treatment of insomnia and in many countries as a premedication before surgery. It is therefore a very useful drug to use for short minor procedures such as dental extraction. Midazolam was first synthesized in 1976 by Fryer and Walser."@en , "Benzodiazepina de semivida corta utilizada como ansiol\u00EDtico o en procesos ligeramente dolorosos. Se utiliza sobre todo por v\u00EDa intravenosa pero se puede dar por v\u00EDa intranasal, rectal, oral o intramuscular. Es un poderoso ansiol\u00EDtico, anest\u00E9sico, hipn\u00F3tico, anticonvulsionante, relajante esqueletomuscular y tiene propiedades sedativas. Es considerado una Benzodiazepina de r\u00E1pido efecto. Gracias a sus propiedades es frecuentemente usado en procedimientos dolorosos cortos, como la extracci\u00F3n dental o la reducci\u00F3n de fracturas. El Midazolam fue sintetizado por primera vez en 1976 por Fryer and Walser."@es , "Midazolam - lek psychotropowy z rodziny benzodiazepin. Charakteryzuje si\u0119 szybkim pocz\u0105tkiem dzia\u0142ania oraz \u015Bredniokr\u00F3tkim czasem dzia\u0142ania. Po podaniu doustnym dzia\u0142a on ok. 4 h, a po podaniu do\u017Cylnym ok. 1 h. Podlega efektowi pierwszego przej\u015Bcia przez w\u0105trob\u0119, dlatego jego biodost\u0119pno\u015B\u0107 przy podaniu doustnym nie przekracza trzydziestu kilku procent."@pl , "Midalozam er ett benzodiazepin-derivat med sedativ og muskelavslappende effekt. I Norge bare tilgjengelig p\u00E5 sykehus som injeksjonsv\u00E6ske under handelsnavnet Dormicum."@no , "O Midazolam (nome IUPAC 8-cloro-6--1-metil-4H-Imidazobenzodiazepina), de formula qu\u00EDmica C18H13ClFN3, \u00E0 semelhan\u00E7a do diazepam, faz parte da classe dos benzodiazep\u00EDnicos. Seu principal mecanismo de a\u00E7\u00E3o \u00E9 nos receptores gabar\u00E9rgicos aumentando a permeabilidade neuronal aos \u00EDons cloretos, colocando a c\u00E9lula em um estado de hiperpolariza\u00E7\u00E3o. Seus principais efeitos s\u00E3o ansi\u00F3lise, relaxamento muscular, amn\u00E9sia e em altas doses pode causar hipnose. As principais vias de administra\u00E7\u00E3o s\u00E3o a oral, intramuscular e endovenosa. Muito utilizado como pr\u00E9-anest\u00E9sico. Pode ser utilizado como agente hipn\u00F3tico em anestesia geral. \u00C9 uma droga muito utilizada como sedativo em cirugias extensivas."@pt , "Il Midazolam \u00E8 una benzodiazepina ad azione ultrabreve utilizzata oggi nel campo dell'anestesia. Somministrabile per via endovenosa, orale ed intranasale. Ha un'azione immediata di sedazione, blanda miorisoluzione e amnesia anterograda. Occasionalmente, specie nei soggetti anziani, il suo smaltimento p\u00F9o risultare rallentato. \u00C8 usato anche come farmaco di induzione dell'ipnosi nei soggetti instabili da un punto di vista emodinamico, proprio perch\u00E9 il farmaco detrmina una minima depressione cardiorespiratoria. Il Midazolam fu sintetizzato per la prima volta nel 1976 da Fryer e Walser"@it , "Midatsolaami on bentsodiatsepiineihin kuuluva l\u00E4\u00E4keaine. Suomessa midatsolaamia myyd\u00E4\u00E4n Dormicum ja Midazolam -tuotenimill\u00E4. Midatsolaamia saa my\u00F6s suoraan laskimoon tai lihakseen annettavana ruiskeena, mutta sit\u00E4 k\u00E4ytet\u00E4\u00E4n p\u00E4\u00E4asiassa vain sairaaloissa - reseptej\u00E4 on kuitenkin mahdollista saada eritt\u00E4in harvinaisissa tapauksissa (l\u00E4hinn\u00E4 mik\u00E4li joudutaan l\u00E4\u00E4keaineen rektaaliseen annosteluun) ja suurien apteekkien on pidett\u00E4v\u00E4 varastossa midatsolaamia my\u00F6s ampullimuodossa. Tablettimuodossa midatsolaamia k\u00E4ytet\u00E4\u00E4n nopeavaikutteisena unil\u00E4\u00E4kkeen\u00E4 lyhytkestoiseen l\u00E4hinn\u00E4 nukahtamisvaikeuksia sis\u00E4lt\u00E4v\u00E4\u00E4n insomniaan. Midatsolaami aiheuttaa muiden bentsodiatsepiinien tapaan usein voimakasta riippuvuutta, joka ilmenee muun muassa l\u00E4\u00E4kkeen v\u00E4hent\u00E4misen tai lopettamisen yhteydess\u00E4 ilmaantuvina vieroitusoireina. Lis\u00E4ksi er\u00E4\u00E4t sivuvaikutukset ovat samanlaisia kuin oireet, joihin l\u00E4\u00E4kitys on aloitettu. Oireiden vaikeutuessa bentsodiatsepiinihoidon aikana onkin aina ep\u00E4ilt\u00E4v\u00E4 sivuvaikutusten ilmaantumista, ennen kuin p\u00E4\u00E4tell\u00E4\u00E4n perustaudin pahentuneen. Jos bentsodiatsepiinia sis\u00E4lt\u00E4v\u00E4\u00E4 l\u00E4\u00E4kevalmistetta k\u00E4ytet\u00E4\u00E4n raskauden aikana, on vaarana, ett\u00E4 vastasyntyneell\u00E4 ilmenee voimakkaita vieroitusoireita."@fi , "Propriet\u0103\u0163i farmacocinetice Absorb\u0163ie dup\u0103 administrare i.m. Absorb\u0163ia midazolamului din \u0163esutul muscular este rapid\u0103 \u015Fi complet\u0103. Concentra\u0163ia plasmatic\u0103 maxim\u0103 se atinge \u00EEn 30 minute. Biodisponibilitatea absolut\u0103 dup\u0103 administrare i.m. este mai mare de 90%. Absorb\u0163ie dup\u0103 administrare reactal\u0103Dup\u0103 administrare rectal\u0103, midazolamul este absorbit rapid. Concentra\u0163ia plasmatic\u0103 maxim\u0103 este atins\u0103 \u00EEn aproximativ 30 minute. Biodisponibilitatea absolut\u0103 este de aproximativ 50%. Distribu\u0163ie C\u00E2nd midazolamul este injectat i.v. , curba concentra\u0163iei plasmatice \u00EEn func\u0163ie de timp prezint\u0103 una sau dou\u0103 faze de distribu\u0163ie distincte. Volumul de distribu\u0163ie la starea de echilibru este de 0,7-1,2 l/kg. Midazolamul se leag\u0103 de proteinele plasmatice \u00EEn propor\u0163ie de 96-98%. Dintre proteinele plasmatice midazolamul se leag\u0103 \u00EEn principal de albumin\u0103. Midazolamul trece lent \u015Fi \u00EEn cantit\u0103\u0163i mici \u00EEn lichidul cefalorahidian. La om, s-a observat c\u0103 midazolamul traverseaz\u0103 bariera feto-placentar\u0103 \u015Fi trece \u00EEn circula\u0163ia f\u0103tului. Cantit\u0103\u0163i mici de midazolam se excret\u0103 \u00EEn laptele matern. Indica\u0163ii terapeutice Midazolamul este un hipnotic cu durat\u0103 scurt\u0103 de ac\u0163iune, indicat \u00EEn: La adul\u0163i - Sedare cu p\u0103strarea st\u0103rii de con\u015Ftien\u0163\u0103 \u00EEnaintea \u015Fi \u00EEn timpul procedurilor diagnostice \u015Fi terapeutice realizate cu sau f\u0103r\u0103 anestezie local\u0103. - Anestezie - premedica\u0163ie \u00EEnainte de induc\u0163ia anesteziei generale; - induc\u0163ia anesteziei; - sedare \u00EEn anestezia combinat\u0103. - Sedare \u00EEn unit\u0103\u0163ile de terapie intensiv\u0103. La copii - Sedare cu p\u0103strarea st\u0103rii de con\u015Ftien\u0163\u0103 \u00EEnaintea \u015Fi \u00EEn timpul procedurilor diagnostice \u015Fi terapeutice realizate cu sau f\u0103r\u0103 anestezie local\u0103; - Anestezie - premedica\u0163ie \u00EEnainte de induc\u0163ia anesteziei generale. - Sedare \u00EEn unit\u0103\u0163ile de terapie intensiv\u0103. (SPC Midazolam) Medico-legal: este cunoscut ca medicamentul violului, cunoscut fiind efectul de amnezie anterograd\u0103."@ro ; rdfs:comment "Benzodiazepina de semivida corta utilizada como ansiol\u00EDtico o en procesos ligeramente dolorosos. Se utiliza sobre todo por v\u00EDa intravenosa pero se puede dar por v\u00EDa intranasal, rectal, oral o intramuscular. Es un poderoso ansiol\u00EDtico, anest\u00E9sico, hipn\u00F3tico, anticonvulsionante, relajante esqueletomuscular y tiene propiedades sedativas. Es considerado una Benzodiazepina de r\u00E1pido efecto."@es , "Le midazolam est une mol\u00E9cule de la famille des benzodiaz\u00E9pines commercialis\u00E9e sous le nom d'Hypnovel \u00AE. Ses puissantes propri\u00E9t\u00E9s anxiolytiques, amn\u00E9siantes, hypnotiques, anticonvulsantes, s\u00E9datives et myorelaxantes, associ\u00E9es \u00E0 un d\u00E9lai et une dur\u00E9e d'action courts, en font un adjuvant particuli\u00E8rement utile en anesth\u00E9sie et en r\u00E9animation."@fr , "Midazolam (Handelsname u. a. Dormicum) ist ein Arzneistoff aus der Gruppe der Benzodiazepine. Es ist verschreibungspflichtig und liegt in Darreichungsformen zur parenteralen und oralen Verabreichung vor. Es kann schon nach kurzer Anwendung zu einer psychischen Abh\u00E4ngigkeit kommen."@de , "Propriet\u0103\u0163i farmacocinetice Absorb\u0163ie dup\u0103 administrare i.m. Absorb\u0163ia midazolamului din \u0163esutul muscular este rapid\u0103 \u015Fi complet\u0103. Concentra\u0163ia plasmatic\u0103 maxim\u0103 se atinge \u00EEn 30 minute. Biodisponibilitatea absolut\u0103 dup\u0103 administrare i.m. este mai mare de 90%. Absorb\u0163ie dup\u0103 administrare reactal\u0103Dup\u0103 administrare rectal\u0103, midazolamul este absorbit rapid. Concentra\u0163ia plasmatic\u0103 maxim\u0103 este atins\u0103 \u00EEn aproximativ 30 minute."@ro , "Midazolam - lek psychotropowy z rodziny benzodiazepin. Charakteryzuje si\u0119 szybkim pocz\u0105tkiem dzia\u0142ania oraz \u015Bredniokr\u00F3tkim czasem dzia\u0142ania. Po podaniu doustnym dzia\u0142a on ok. 4 h, a po podaniu do\u017Cylnym ok. 1 h. Podlega efektowi pierwszego przej\u015Bcia przez w\u0105trob\u0119, dlatego jego biodost\u0119pno\u015B\u0107 przy podaniu doustnym nie przekracza trzydziestu kilku procent."@pl , "Midazolam, pronounced /m\u026A\u02C8d\u00E6z\u0259l\u00E6m/ (and marketed in English-speaking countries under brand names Dormicum, Hypnovel, Midacum and Versed) is an ultra short-acting benzodiazepine derivative. It has potent anxiolytic, amnestic, hypnotic, anticonvulsant, skeletal muscle relaxant, and sedative properties. Midazolam is water-soluble and fat-soluble in physiologic pH. Freely soluble in alcohol and acetone."@en , "F\u00E1jl:Midazolam. svg A midazol\u00E1m szerkezeti k\u00E9plete A midazol\u00E1m (Dormicum) egy ultra r\u00F6vid hat\u00E1s\u00FA benzodiazepin sz\u00E1rmaz\u00E9k. Er\u0151s anxiol\u00EDtikus, amn\u00E9zia-kiv\u00E1lt\u00F3, hipnotikus, antikonvulz\u00EDv, v\u00E1zizomrelax\u00E1ns \u00E9s nyugtat\u00F3 tulajdons\u00E1gai vannak. A midazolam molekul\u00E1ja k\u00FCl\u00F6nleges a benzodiazepinek k\u00F6r\u00E9ben, mivel v\u00EDzben oldhat\u00F3 \u00E9s nem zs\u00EDrban old\u00F3d\u00F3, mint a legt\u00F6bb benzodiazepin. Ultra r\u00F6vid hat\u00E1s\u00FA benzodiazepin, az elimin\u00E1ci\u00F3s felez\u00E9si ideje k\u00F6r\u00FClbel\u00FCl 2 \u00F3ra."@hu , "Midatsolaami on bentsodiatsepiineihin kuuluva l\u00E4\u00E4keaine. Suomessa midatsolaamia myyd\u00E4\u00E4n Dormicum ja Midazolam -tuotenimill\u00E4. Midatsolaamia saa my\u00F6s suoraan laskimoon tai lihakseen annettavana ruiskeena, mutta sit\u00E4 k\u00E4ytet\u00E4\u00E4n p\u00E4\u00E4asiassa vain sairaaloissa - reseptej\u00E4 on kuitenkin mahdollista saada eritt\u00E4in harvinaisissa tapauksissa (l\u00E4hinn\u00E4 mik\u00E4li joudutaan l\u00E4\u00E4keaineen rektaaliseen annosteluun) ja suurien apteekkien on pidett\u00E4v\u00E4 varastossa midatsolaamia my\u00F6s ampullimuodossa."@fi , "Il Midazolam \u00E8 una benzodiazepina ad azione ultrabreve utilizzata oggi nel campo dell'anestesia. Somministrabile per via endovenosa, orale ed intranasale. Ha un'azione immediata di sedazione, blanda miorisoluzione e amnesia anterograda. Occasionalmente, specie nei soggetti anziani, il suo smaltimento p\u00F9o risultare rallentato."@it , "Midalozam er ett benzodiazepin-derivat med sedativ og muskelavslappende effekt. I Norge bare tilgjengelig p\u00E5 sykehus som injeksjonsv\u00E6ske under handelsnavnet Dormicum."@no , "\u041C\u0438\u0434\u0430\u0437\u043E\u043B\u0430\u043C (Midazolam) 8-\u0425\u043B\u043E\u0440-6-(2-\u0444\u0442\u043E\u0440\u0444\u0435\u043D\u0438\u043B)-1-\u043C\u0435\u0442\u0438\u043B-4H-\u0438\u043C\u0438\u0434\u0430\u0437\u043E/1,5-a//1,4/\u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D (\u0432 \u0432\u0438\u0434\u0435 \u0433\u0438\u0434\u0440\u043E\u0445\u043B\u043E\u0440\u0438\u0434\u0430 \u0438\u043B\u0438 \u043C\u0430\u043B\u0435\u0430\u0442\u0430) \u0421\u0438\u043D\u043E\u043D\u0438\u043C\u044B: \u0424\u043B\u043E\u0440\u043C\u0438\u0434\u0430\u043B, Dormicum, Dormonid, Flormidal, Versed."@ru , "Midazolam, (merknaam Dormicum\u00AE van Roche en in de VS Versed\u00AEen Hypnovel\u00AE) hoort bij de benzodiazepines. Het heeft sterke anxiolytische, amnestische, hypnotische, anticonvulsieve, spierrelaxerende en sedatieve eigenschappen. Het is een snelwerkende benzodiazepine, de groep medicijnen waar Xanax\u00AE en Valium\u00AE ook toe behoren. Het is een van de weinige wateroplosbare benzodiazepines, en daarom erg geschikt voor injectie. Midazolam is voor het eerst gesynthetiseerd in 1976 door Fryer en Walser."@nl , "O Midazolam (nome IUPAC 8-cloro-6--1-metil-4H-Imidazobenzodiazepina), de formula qu\u00EDmica C18H13ClFN3, \u00E0 semelhan\u00E7a do diazepam, faz parte da classe dos benzodiazep\u00EDnicos. Seu principal mecanismo de a\u00E7\u00E3o \u00E9 nos receptores gabar\u00E9rgicos aumentando a permeabilidade neuronal aos \u00EDons cloretos, colocando a c\u00E9lula em um estado de hiperpolariza\u00E7\u00E3o. Seus principais efeitos s\u00E3o ansi\u00F3lise, relaxamento muscular, amn\u00E9sia e em altas doses pode causar hipnose."@pt , "Midazolam, C18H13ClFN3, \u00E4r ett \u00E5ngestd\u00E4mpande och lugnande preparat som tillh\u00F6r gruppen bensodiazepiner, patenterat 1976. \u00C4mnet \u00E4r narkotikaklassat. Varunamn i Sverige \u00E4r bland annat Dormicum och Midazolam Alpharma. L\u00E4kemedlet finns b\u00E5de som oral suspention eller som injektionsform. Midazolam anv\u00E4nds vid oro, \u00E5ngest och sp\u00E4nning d\u00E5 snabb effekt \u00F6nskas, till exempel i samband med operationer eller obehagliga unders\u00F6kningar."@sv , "\u30DF\u30C0\u30BE\u30E9\u30E0 (midazolam) \u3068\u306F\u30D9\u30F3\u30BE\u30B8\u30A2\u30BC\u30D4\u30F3(BZP)\u7CFB\u306E\u9EBB\u9154\u5C0E\u5165\u85AC\u30FB\u93AE\u9759\u85AC\u3002\u65E5\u672C\u3067\u306E\u5546\u54C1\u540D\u306F\u30C9\u30EB\u30DF\u30AB\u30E0\uFF08\u30A2\u30B9\u30C6\u30E9\u30B9\u88FD\u85AC\u88FD\u9020\u8CA9\u58F2\uFF09\u3002\uFF08\u5F8C\u767A\u54C1\u3042\u308A\uFF09"@ja ; foaf:depiction . @prefix skos: . @prefix ns11: . dbpedia:Midazolam skos:subject ns11:Benzodiazepines , ns11:Muscle_relaxants , ns11:Anxiolytics , ns11:Anticonvulsants , ns11:Hypnotics , ns11:Imidazoles , ns11:Sedatives . @prefix ns12: . dbpedia:Midazolam dbpprop:wikiPageUsesTemplate ns12:drugbox ; dbpprop:c 18 ; dbpprop:h 13 ; dbpprop:n 3 ; dbpprop:f 1 ; dbpprop:iupacName "8-chloro- 6-(2-fluorophenyl)- 1-methyl- 4H-imidazo[1,5-a] [1,4]benzodiazepine"@en ; dbpprop:width 140 ; dbpprop:atcPrefix "N05"@en ; dbpprop:cl 1 ; dbpprop:casNumber "59467-70-8"@en ; dbpprop:verifiedrevid 307699332 ; dbpprop:image "Midazolam3d.png"@en , "Midazolam.JPG"@en , "Dormicum.JPG"@en ; dbpprop:atcSuffix "CD08"@en ; dbpprop:metabolism dbpedia:Liver ; dbpprop:excretion dbpedia:Kidney ; dbpprop:pubchem 4192 ; dbpprop:molecularWeight 325.78 ; dbpprop:chemspiderid 4047 ; dbpprop:eliminationHalfLife "1.8-6.4 hours"@en ; dbpprop:legalStatus dbpedia:Schedule_IV_controlled_substance ; dbpprop:drugbank "APRD00680"@en ; dbpprop:pregnancyCategory "D
C"@en ; dbpprop:routesOfAdministration "Oral, I.M., I.V., parenteral"@en ; dbpprop:bioavailability "Oral ~36% \nI.M. 90%+"@en . @prefix ns13: . dbpedia:Midazolam dbpprop:hasPhotoCollection ns13:Midazolam . dbpedia:Midazolam_hydrochloride dbpprop:redirect dbpedia:Midazolam . dbpedia:C18H13ClFN3 dbpprop:redirect dbpedia:Midazolam . dbpedia:Dormicum dbpprop:redirect dbpedia:Midazolam . dbpedia:Dormonid dbpprop:redirect dbpedia:Midazolam . dbpedia:Hypnovel dbpprop:redirect dbpedia:Midazolam . dbpedia:Versed dbpprop:redirect dbpedia:Midazolam . @prefix yago: . yago:Midazolam owl:sameAs dbpedia:Midazolam .