@prefix dbpprop: .
@prefix dbpedia: .
dbpedia:Carbatrol dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Finlepsin dbpprop:redirect dbpedia:Carbamazepine .
@prefix rdf: .
@prefix dbpedia-owl: .
dbpedia:Carbamazepine rdf:type dbpedia-owl:Drug .
@prefix owl: .
dbpedia:Carbamazepine rdf:type owl:Thing .
@prefix opencyc: .
dbpedia:Carbamazepine rdf:type opencyc:Mx4rwHBxKJwpEbGdrcN5Y29ycA .
@prefix ns6: .
dbpedia:Carbamazepine rdf:type ns6:Prodrugs ,
ns6:Carboxamides ;
owl:sameAs .
@prefix ns7: .
dbpedia:Carbamazepine owl:sameAs ns7:Carbamazepine ,
opencyc:Mx4rwE1L6pwpEbGdrcN5Y29ycA .
@prefix ns8: .
dbpedia:Carbamazepine owl:sameAs ns8:Mx4rwE1L6pwpEbGdrcN5Y29ycA .
@prefix foaf: .
@prefix ns10: .
dbpedia:Carbamazepine foaf:page ns10:Carbamazepine .
@prefix ns11: .
dbpedia:Carbamazepine ns11:atcPrefix "N03" ;
ns11:atcSuffix "AF01" ;
ns11:casNumber "298-46-4" ;
ns11:casSupplemental "(dihydrate)" ;
dbpedia-owl:drugbank "APRD00337" ;
ns11:drugbank "APRD00337" ;
ns11:iupacName "5H-dibenzo[b,f]azepine-5-carboxamide" ;
dbpedia-owl:pubchem "2554" ;
dbpprop:reference ,
,
,
,
,
.
@prefix rdfs: .
dbpedia:Carbamazepine rdfs:label "Carbamazepina"@es ,
"Karbamazepin"@hu ,
"Karbamazepin"@sv ,
"Carbamazepina"@it ,
"Karbamazepin"@no ,
"Carbamazepin"@de ,
"\u5361\u9A6C\u897F\u5E73"@zh ,
"Carbamaz\u00E9pine"@fr ,
"\u30AB\u30EB\u30D0\u30DE\u30BC\u30D4\u30F3"@ja ,
"Carbamazepina"@pt ,
"Karbamazepina"@pl ,
"Carbamazepine"@en ,
"Carbamazepine"@nl ,
"\u041A\u0430\u0440\u0431\u0430\u043C\u0430\u0437\u0435\u043F\u0438\u043D"@ru ;
dbpedia-owl:thumbnail ;
dbpedia-owl:atcPrefix "N03" ;
dbpedia-owl:atcSuffix "AF01" ;
dbpedia-owl:casNumber "298-46-4" ;
dbpedia-owl:casSupplemental "(dihydrate)" ;
dbpedia-owl:iupacName "5H-dibenzo[b,f]azepine-5-carboxamide" ;
ns11:pubchem "2554" ;
dbpprop:abstract "Carbamazepine (CBZ) is an anticonvulsant and mood stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It is also used off-label for a variety of indications, including attention-deficit hyperactivity disorder (ADHD), schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, and post-traumatic stress disorder."@en ,
"\u5361\u99AC\u897F\u5E73\uFF08Carbamazepine\uFF09"@zh ,
"La carbamazepina es un f\u00E1rmaco antiepil\u00E9ptico y estabilizador del \u00E1nimo, usado principalmente para el tratamiento de la epilepsia y del trastorno bipolar. En ocasiones tambi\u00E9n se utiliza para tratar la esquizofrenia y la neuralgia del trig\u00E9mino."@es ,
"\u30AB\u30EB\u30D0\u30DE\u30BC\u30D4\u30F3\u306F\u3001\u3066\u3093\u304B\u3093\u306E\u767A\u4F5C\u3084\u5411\u7CBE\u795E\u85AC\u3068\u3057\u3066\u4F7F\u308F\u308C\u308B\u85AC\u306E\u4E00\u7A2E\u3067\u3042\u308B\u3002\u8133\u795E\u7D4C\u7D30\u80DE\u306ENa\u30C1\u30E3\u30CD\u30EB\u3092\u906E\u65AD\u3059\u308B\u3002\u4E00\u822C\u7684\u306B\u819C\u6D3B\u52D5\u96FB\u4F4D\u306E\u7ACB\u3061\u4E0A\u304C\u308A\u304C\u963B\u5BB3\u3055\u308C\u308B\u305F\u3081\u3001\u795E\u7D4C\u7D30\u80DE\u306E\u8907\u96D1\u90E8\u5206\u767A\u4F5C\u306B\u52B9\u679C\u304C\u3042\u308B\u3068\u3055\u308C\u3066\u304A\u308A\u3001\u305F\u3068\u3048\u3070\u3066\u3093\u304B\u3093\u306E\u5074\u982D\u8449\u90E8\u5206\u767A\u4F5C\u7279\u52B9\u85AC\u3068\u3057\u3066\u7528\u3044\u3089\u308C\u3066\u3044\u308B\u3002 \u9577\u3089\u304F\u4E09\u53C9\u795E\u7D4C\u75DB\u306E\u85AC\u3068\u3057\u3066\u3082\u4F7F\u7528\u3055\u308C\u3066\u304D\u305F\u304C\u3001\u6700\u8FD1\u3067\u306F\u795E\u7D4C\u75C7\u306E\u3072\u3068\u3064\u3067\u3042\u308B\u53CC\u6975\u6027\u969C\u5BB3\u306E\u85AC\u3068\u3057\u3066\u3082\u7528\u3044\u3089\u308C\u308B\u3088\u3046\u306B\u306A\u3063\u305F\u3002"@ja ,
"Karbamazepin, eng. Carbamazepine. Kemiskt namn 5H-Dibens[b,f]azepin-5-karboxamid. Substans som mildrar elektriska signalers utbredning i hj\u00E4rnan. Framg\u00E5ngsrikt anv\u00E4nt fr\u00E4mst mot olika former av epilepsi, alkoholabstinens och trigeminusneuralgi. Kan ocks\u00E5 anv\u00E4ndas mot vissa former av ADHD och s.k. temporallobsdysfunktion. Karbamazepin har kemiska likheter med tricykliska antidepressiva (TCA) och anses ha en svag antidepressiv effekt. Karbamazepin kan liksom andra epilepsimediciner anv\u00E4ndas vid bipolar (mano-depressiv) sjukdom - ibland i kombination med litium. Finns tillg\u00E4ngligt bland annat under varum\u00E4rkena Tegretol, Trimonil och Hermolepsin."@sv ,
"Karbamazepina \u2013 lek psychotropowy, pochodna dibenzoazepiny (iminostilbenu) o strukturze zbli\u017Conej do tr\u00F3jpier\u015Bcieniowych lek\u00F3w przeciwdepresyjnych, lek przeciwdrgawkowy i stabilizuj\u0105cy nastr\u00F3j, u\u017Cywany g\u0142\u00F3wnie do leczenia padaczki i choroby afektywnej dwubiegunowej. U\u017Cywa si\u0119 go r\u00F3wnie\u017C do leczenia schizofrenii oraz neuralgii tr\u00F3jdzielnej. Przy wieloletnim stosowaniu karbamazepiny nast\u0119puje rozmi\u0119kanie ko\u015Bci ze wzgl\u0119du na przyspieszenie metabolizmu witaminy D w w\u0105trobie. Lek ten przy d\u0142ugotrwa\u0142ym za\u017Cywaniu powoduje uszkodzenie cia\u0142ek krwi, w szczeg\u00F3lno\u015Bci trombocyt\u00F3w. W Polsce sprzedawany m. in. pod nast\u0119puj\u0105cymi nazwami handlowymi: Amizepin, Finlepsin, Neurotop, Tegretol, Timonil."@pl ,
"La carbamazepina \u00E8 uno dei principali farmaci usati nel trattamento dell'epilessia. Deriva chimicamente da farmaci antidepressivi triciclici a struttura dibenzo-azepinica, e venne scoperta nel corso dello screening di molecole in grado di inibire la crisi indotta dalla stimolazione elettrica nel topo. La sua azione pi\u00F9 nota a livello del sistema nervoso \u00E8 quella di rallentare il recupero dei canali al sodio, sebbene abbia anche effetti metabolici importanti interferendo con il ciclo degli inositoli e con la GSK (glicogeno-sintetasi-chinasi)."@it ,
"Karbamazepin er et legemiddel, et antiepileptikum. Karbamazepin markedsf\u00F8res i Norge under varemerkene Tegretol og Trimonil."@no ,
"\u041A\u0430\u0440\u0431\u0430\u043C\u0430\u0437\u0435\u043F\u0438\u043D (Carbamazepinum, 5-\u041A\u0430\u0440\u0431\u0430\u043C\u043E\u0438\u043B-5\u041D-\u0434\u0438\u0431\u0435\u043D\u0437)\u00A0\u2014 \u043B\u0435\u043A\u0430\u0440\u0441\u0442\u0432\u0435\u043D\u043D\u043E\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043E. \u0411\u0435\u043B\u043E\u0435 \u043A\u0440\u0438\u0441\u0442\u0430\u043B\u043B\u0438\u0447\u0435\u0441\u043A\u043E\u0435 \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u043E, \u043D\u0435 \u0440\u0430\u0441\u0442\u0432\u043E\u0440\u0438\u043C\u043E\u0435 \u0432 \u0432\u043E\u0434\u0435. \u0421\u0438\u043D\u043E\u043D\u0438\u043C\u044B: \u0421\u0442\u0430\u0437\u0435\u043F\u0438\u043D, \u0422\u0435\u0433\u0440\u0435\u0442\u043E\u043B, \u0424\u0438\u043D\u043B\u0435\u043F\u0441\u0438\u043D, \u0422\u0438\u043C\u043E\u043D\u0438\u043B, Amizepin, Carbagretil, Carbamazepin, Carbazep, Finlepsin, Mazetol, Neurotop, Timonil, Stazepin, Tegretal, Tegretol, Temporal, Zeptol \u0438 \u0434\u0440."@ru ,
"La carbamaz\u00E9pine est un m\u00E9dicament soignant l'\u00E9pilepsie et r\u00E9gulant l'humeur."@fr ,
"M\u00EDg a karbamazepin g\u00F6rcsg\u00E1tl\u00F3 tulajdons\u00E1g\u00E1\u00E9rt f\u0151leg a glutam\u00E1t-felszabadul\u00E1s cs\u00F6kkent\u00E9se \u00E9s az idegsejt-membr\u00E1n stabiliz\u00E1l\u00E1sa, addig antimani\u00E1s hat\u00E1s\u00E1\u00E9rt a dopamin \u00E9s noradrenalin turnover cs\u00F6kkent\u00E9se lehet felel\u0151s."@hu ,
"Carbamazepin z\u00E4hlt chemisch zur Klasse der Dibenzazepine und ist ein Antiepileptikum, das vorwiegend gegen fokale Epilepsien eingesetzt wird. Dar\u00FCber hinaus wird es auch als Phasenprophylaktikum bei verschiedenen psychiatrischen Erkrankungen eingesetzt. Strukturchemisch ist es dem Imipramin sehr \u00E4hnlich."@de ,
"Carbamazepine is een anti-epilepticum; een medicijn dat de verschijnselen van epilepsie onderdrukt. Het wordt ook voorgeschreven tijdens een manische fase. Het exacte werkingsmechanisme is onbekend. Carbamezepine wordt in Nederland op de markt gebracht onder de namen: Carbamazepine, Carbymal en Tegretol. Er wordt gewaarschuwd voor mogelijke interactie met verschillende stoffen, waaronder alcohol en spierverslappers."@nl ,
"A carbamazepina \u00E9 um dos principais f\u00E1rmacos utilizados no tratamento da epilepsia."@pt ;
rdfs:comment "M\u00EDg a karbamazepin g\u00F6rcsg\u00E1tl\u00F3 tulajdons\u00E1g\u00E1\u00E9rt f\u0151leg a glutam\u00E1t-felszabadul\u00E1s cs\u00F6kkent\u00E9se \u00E9s az idegsejt-membr\u00E1n stabiliz\u00E1l\u00E1sa, addig antimani\u00E1s hat\u00E1s\u00E1\u00E9rt a dopamin \u00E9s noradrenalin turnover cs\u00F6kkent\u00E9se lehet felel\u0151s."@hu ,
"Karbamazepin, eng. Carbamazepine. Kemiskt namn 5H-Dibens[b,f]azepin-5-karboxamid. Substans som mildrar elektriska signalers utbredning i hj\u00E4rnan. Framg\u00E5ngsrikt anv\u00E4nt fr\u00E4mst mot olika former av epilepsi, alkoholabstinens och trigeminusneuralgi. Kan ocks\u00E5 anv\u00E4ndas mot vissa former av ADHD och s.k. temporallobsdysfunktion. Karbamazepin har kemiska likheter med tricykliska antidepressiva (TCA) och anses ha en svag antidepressiv effekt."@sv ,
"A carbamazepina \u00E9 um dos principais f\u00E1rmacos utilizados no tratamento da epilepsia."@pt ,
""@ja ,
"Carbamazepin z\u00E4hlt chemisch zur Klasse der Dibenzazepine und ist ein Antiepileptikum, das vorwiegend gegen fokale Epilepsien eingesetzt wird. Dar\u00FCber hinaus wird es auch als Phasenprophylaktikum bei verschiedenen psychiatrischen Erkrankungen eingesetzt. Strukturchemisch ist es dem Imipramin sehr \u00E4hnlich."@de ,
"La carbamazepina \u00E8 uno dei principali farmaci usati nel trattamento dell'epilessia. Deriva chimicamente da farmaci antidepressivi triciclici a struttura dibenzo-azepinica, e venne scoperta nel corso dello screening di molecole in grado di inibire la crisi indotta dalla stimolazione elettrica nel topo."@it ,
"Karbamazepina \u2013 lek psychotropowy, pochodna dibenzoazepiny (iminostilbenu) o strukturze zbli\u017Conej do tr\u00F3jpier\u015Bcieniowych lek\u00F3w przeciwdepresyjnych, lek przeciwdrgawkowy i stabilizuj\u0105cy nastr\u00F3j, u\u017Cywany g\u0142\u00F3wnie do leczenia padaczki i choroby afektywnej dwubiegunowej. U\u017Cywa si\u0119 go r\u00F3wnie\u017C do leczenia schizofrenii oraz neuralgii tr\u00F3jdzielnej. Przy wieloletnim stosowaniu karbamazepiny nast\u0119puje rozmi\u0119kanie ko\u015Bci ze wzgl\u0119du na przyspieszenie metabolizmu witaminy D w w\u0105trobie."@pl ,
"\u041A\u0430\u0440\u0431\u0430\u043C\u0430\u0437\u0435\u043F\u0438\u043D (Carbamazepinum, 5-\u041A\u0430\u0440\u0431\u0430\u043C\u043E\u0438\u043B-5\u041D-\u0434\u0438\u0431\u0435\u043D\u0437)\u00A0\u2014 \u043B\u0435\u043A\u0430\u0440\u0441\u0442\u0432\u0435\u043D\u043D\u043E\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043E. \u0411\u0435\u043B\u043E\u0435 \u043A\u0440\u0438\u0441\u0442\u0430\u043B\u043B\u0438\u0447\u0435\u0441\u043A\u043E\u0435 \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u043E, \u043D\u0435 \u0440\u0430\u0441\u0442\u0432\u043E\u0440\u0438\u043C\u043E\u0435 \u0432 \u0432\u043E\u0434\u0435. \u0421\u0438\u043D\u043E\u043D\u0438\u043C\u044B: \u0421\u0442\u0430\u0437\u0435\u043F\u0438\u043D, \u0422\u0435\u0433\u0440\u0435\u0442\u043E\u043B, \u0424\u0438\u043D\u043B\u0435\u043F\u0441\u0438\u043D, \u0422\u0438\u043C\u043E\u043D\u0438\u043B, Amizepin, Carbagretil, Carbamazepin, Carbazep, Finlepsin, Mazetol, Neurotop, Timonil, Stazepin, Tegretal, Tegretol, Temporal, Zeptol \u0438 \u0434\u0440."@ru ,
"Carbamazepine (CBZ) is an anticonvulsant and mood stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It is also used off-label for a variety of indications, including attention-deficit hyperactivity disorder (ADHD), schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, and post-traumatic stress disorder."@en ,
"La carbamazepina es un f\u00E1rmaco antiepil\u00E9ptico y estabilizador del \u00E1nimo, usado principalmente para el tratamiento de la epilepsia y del trastorno bipolar. En ocasiones tambi\u00E9n se utiliza para tratar la esquizofrenia y la neuralgia del trig\u00E9mino."@es ,
"Carbamazepine is een anti-epilepticum; een medicijn dat de verschijnselen van epilepsie onderdrukt. Het wordt ook voorgeschreven tijdens een manische fase. Het exacte werkingsmechanisme is onbekend. Carbamezepine wordt in Nederland op de markt gebracht onder de namen: Carbamazepine, Carbymal en Tegretol. Er wordt gewaarschuwd voor mogelijke interactie met verschillende stoffen, waaronder alcohol en spierverslappers."@nl ,
"\u5361\u99AC\u897F\u5E73\uFF08Carbamazepine\uFF09"@zh ,
"La carbamaz\u00E9pine est un m\u00E9dicament soignant l'\u00E9pilepsie et r\u00E9gulant l'humeur."@fr ,
"Karbamazepin er et legemiddel, et antiepileptikum. Karbamazepin markedsf\u00F8res i Norge under varemerkene Tegretol og Trimonil."@no ;
foaf:depiction .
@prefix skos: .
@prefix ns14: .
dbpedia:Carbamazepine skos:subject ns14:World_Health_Organization_essential_medicines ,
ns14:Anticonvulsants ,
ns14:Ureas ,
ns14:Mood_stabilizers ,
ns14:Prodrugs .
@prefix ns15: .
dbpedia:Carbamazepine dbpprop:wikiPageUsesTemplate ns15:drugbox ;
dbpprop:c 15 ;
dbpprop:h 12 ;
dbpprop:n 2 ;
dbpprop:o 1 ;
dbpprop:iupacName "5H-dibenzo[b,f]azepine-5-carboxamide"@en ;
dbpprop:width 127 ;
dbpprop:atcPrefix "N03"@en .
@prefix xsd: .
dbpedia:Carbamazepine dbpprop:casNumber "0298-46-04"^^xsd:date ;
dbpprop:verifiedrevid 306163854 ;
dbpprop:image "Carbamazepine 3D.png"@en ;
dbpprop:atcSuffix "AF01"@en ;
dbpprop:metabolism " Hepatic\u2014by CYP3A4, to active epoxide form (carbamazepine-10,11 epoxide)"@en ;
dbpprop:excretion "2\u20133% excreted unchanged in urine"@en ;
dbpprop:casSupplemental "dihydrate)"@en ;
dbpprop:proteinBound "76"^^dbpedia-owl:Percent ;
dbpprop:pubchem 2554 ;
dbpprop:molecularWeight "236.269 g/mol"@en ;
dbpprop:chemspiderid 2457 ;
dbpprop:eliminationHalfLife "25\u201365 hours"@en ;
dbpprop:pregnancyUs "D"@en ;
dbpprop:legalUs "Rx-only"@en ;
dbpprop:legalUk "POM"@en ;
dbpprop:drugbank "APRD00337"@en ;
dbpprop:routesOfAdministration "Oral"@en ;
dbpprop:bioavailability "80"^^dbpedia-owl:Percent .
@prefix ns17: .
dbpedia:Carbamazepine dbpprop:hasPhotoCollection ns17:Carbamazepine .
dbpedia:Epitol dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Calepsin dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Equetro dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Stazepine dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Tegretol-xr dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Carbamazapine dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Carbimazepine dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Telesmin dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Timonil dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Tegretol dbpprop:redirect dbpedia:Carbamazepine .
dbpedia:Sirtal dbpprop:redirect dbpedia:Carbamazepine .
@prefix ns18: .
ns18:DB00564 owl:sameAs dbpedia:Carbamazepine .
@prefix yago: .
yago:Carbamazepine owl:sameAs dbpedia:Carbamazepine .